The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1

Mutations in leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and sporadic Parkinson’s disease (PD). LRRK2 is a complex protein that consists of multiple domains, including 13 putative armadillo-type repeats at the N-terminus. In this study, we analyzed the functional and molec...

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Detalles Bibliográficos
Autores principales: Perez Carrion, Maria, Pischedda, Francesca, Biosa, Alice, Russo, Isabella, Straniero, Letizia, Civiero, Laura, Guida, Marianna, Gloeckner, Christian J., Ticozzi, Nicola, Tiloca, Cinzia, Mariani, Claudio, Pezzoli, Gianni, Duga, Stefano, Pichler, Irene, Pan, Lifeng, Landers, John E., Greggio, Elisa, Hess, Michael W., Goldwurm, Stefano, Piccoli, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835904/
https://www.ncbi.nlm.nih.gov/pubmed/29541021
http://dx.doi.org/10.3389/fnmol.2018.00064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835904/
https://www.ncbi.nlm.nih.gov/pubmed/29541021
http://dx.doi.org/10.3389/fnmol.2018.00064

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