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Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms

Many organic sulfur, selenium and tellurium compounds show considerable activity against microorganisms, including bacteria and fungi. This pronounced activity is often due to the specific, oxidizing redox behavior of the chalcogen-chalcogen bond present in such molecules. Interestingly, similar cha...

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Autores principales: Griffin, Sharoon, Sarfraz, Muhammad, Hartmann, Steffen F., Pinnapireddy, Shashank Reddy, Nasim, Muhammad Jawad, Bakowsky, Udo, Keck, Cornelia M., Jacob, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836013/
https://www.ncbi.nlm.nih.gov/pubmed/29382037
http://dx.doi.org/10.3390/antiox7020023
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author Griffin, Sharoon
Sarfraz, Muhammad
Hartmann, Steffen F.
Pinnapireddy, Shashank Reddy
Nasim, Muhammad Jawad
Bakowsky, Udo
Keck, Cornelia M.
Jacob, Claus
author_facet Griffin, Sharoon
Sarfraz, Muhammad
Hartmann, Steffen F.
Pinnapireddy, Shashank Reddy
Nasim, Muhammad Jawad
Bakowsky, Udo
Keck, Cornelia M.
Jacob, Claus
author_sort Griffin, Sharoon
collection PubMed
description Many organic sulfur, selenium and tellurium compounds show considerable activity against microorganisms, including bacteria and fungi. This pronounced activity is often due to the specific, oxidizing redox behavior of the chalcogen-chalcogen bond present in such molecules. Interestingly, similar chalcogen-chalcogen motifs are also found in the elemental forms of these elements, and while those materials are insoluble in aqueous media, it has recently been possible to unlock their biological activities using naturally produced or homogenized suspensions of respective chalcogen nanoparticles. Those suspensions can be employed readily and often effectively against common pathogenic microorganisms, still their practical uses are limited as such suspensions are difficult to transport, store and apply. Using mannitol as stabilizer, it is now possible to lyophilize such suspensions to produce solid forms of the nanoparticles, which upon resuspension in water essentially retain their initial size and exhibit considerable biological activity. The sequence of Nanosizing, Lyophilization and Resuspension (NaLyRe) eventually provides access to a range of lyophilized materials which may be considered as easy-to-handle, ready-to-use and at the same time as bioavailable, active forms of otherwise insoluble or sparingly substances. In the case of elemental sulfur, selenium and tellurium, this approach promises wider practical applications, for instance in the medical or agricultural arena.
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spelling pubmed-58360132018-03-07 Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms Griffin, Sharoon Sarfraz, Muhammad Hartmann, Steffen F. Pinnapireddy, Shashank Reddy Nasim, Muhammad Jawad Bakowsky, Udo Keck, Cornelia M. Jacob, Claus Antioxidants (Basel) Article Many organic sulfur, selenium and tellurium compounds show considerable activity against microorganisms, including bacteria and fungi. This pronounced activity is often due to the specific, oxidizing redox behavior of the chalcogen-chalcogen bond present in such molecules. Interestingly, similar chalcogen-chalcogen motifs are also found in the elemental forms of these elements, and while those materials are insoluble in aqueous media, it has recently been possible to unlock their biological activities using naturally produced or homogenized suspensions of respective chalcogen nanoparticles. Those suspensions can be employed readily and often effectively against common pathogenic microorganisms, still their practical uses are limited as such suspensions are difficult to transport, store and apply. Using mannitol as stabilizer, it is now possible to lyophilize such suspensions to produce solid forms of the nanoparticles, which upon resuspension in water essentially retain their initial size and exhibit considerable biological activity. The sequence of Nanosizing, Lyophilization and Resuspension (NaLyRe) eventually provides access to a range of lyophilized materials which may be considered as easy-to-handle, ready-to-use and at the same time as bioavailable, active forms of otherwise insoluble or sparingly substances. In the case of elemental sulfur, selenium and tellurium, this approach promises wider practical applications, for instance in the medical or agricultural arena. MDPI 2018-01-27 /pmc/articles/PMC5836013/ /pubmed/29382037 http://dx.doi.org/10.3390/antiox7020023 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Griffin, Sharoon
Sarfraz, Muhammad
Hartmann, Steffen F.
Pinnapireddy, Shashank Reddy
Nasim, Muhammad Jawad
Bakowsky, Udo
Keck, Cornelia M.
Jacob, Claus
Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms
title Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms
title_full Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms
title_fullStr Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms
title_full_unstemmed Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms
title_short Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms
title_sort resuspendable powders of lyophilized chalcogen particles with activity against microorganisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836013/
https://www.ncbi.nlm.nih.gov/pubmed/29382037
http://dx.doi.org/10.3390/antiox7020023
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