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Octodrine: New Questions and Challenges in Sport Supplements

Background: Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950’s, it has recently been re-introduced on the market as a pre-workout and ‘fat-burner’ p...

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Autores principales: Catalani, Valeria, Prilutskaya, Mariya, Al-Imam, Ahmed, Marrinan, Shanna, Elgharably, Yasmine, Zloh, Mire, Martinotti, Giovanni, Chilcott, Robert, Corazza, Ornella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836053/
https://www.ncbi.nlm.nih.gov/pubmed/29461475
http://dx.doi.org/10.3390/brainsci8020034
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author Catalani, Valeria
Prilutskaya, Mariya
Al-Imam, Ahmed
Marrinan, Shanna
Elgharably, Yasmine
Zloh, Mire
Martinotti, Giovanni
Chilcott, Robert
Corazza, Ornella
author_facet Catalani, Valeria
Prilutskaya, Mariya
Al-Imam, Ahmed
Marrinan, Shanna
Elgharably, Yasmine
Zloh, Mire
Martinotti, Giovanni
Chilcott, Robert
Corazza, Ornella
author_sort Catalani, Valeria
collection PubMed
description Background: Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950’s, it has recently been re-introduced on the market as a pre-workout and ‘fat-burner’ product but its use remains unregulated. Our work provides the first observational cross-sectional analytic study on Octodrine as a new drug trend and its associated harms after a gap spanning seven decades. Methods: A comprehensive multilingual assessment of literature, websites, drug fora and other online resources was carried out with no time restriction in English, German, Russian and Arabic. Keywords included Octodrine’s synonyms and chemical isomers. Results: Only five relevant publications emerged from the literature search, with most of the available data on body building websites and fora. Since 2015, Octodrine has been advertised online as “the next big thing” and “the god of stimulants,” with captivating marketing strategies directed at athletes and a wider cohort of users. Reported side-effects include hypertension, dyspnoea and hyperthermia. Conclusions: The uncontrolled use of Octodrine, its physiological and psychoactive effects raise serious health implications with possible impact on athletes and doping practices. This new phenomenon needs to be thoroughly studied and monitored.
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spelling pubmed-58360532018-03-07 Octodrine: New Questions and Challenges in Sport Supplements Catalani, Valeria Prilutskaya, Mariya Al-Imam, Ahmed Marrinan, Shanna Elgharably, Yasmine Zloh, Mire Martinotti, Giovanni Chilcott, Robert Corazza, Ornella Brain Sci Article Background: Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950’s, it has recently been re-introduced on the market as a pre-workout and ‘fat-burner’ product but its use remains unregulated. Our work provides the first observational cross-sectional analytic study on Octodrine as a new drug trend and its associated harms after a gap spanning seven decades. Methods: A comprehensive multilingual assessment of literature, websites, drug fora and other online resources was carried out with no time restriction in English, German, Russian and Arabic. Keywords included Octodrine’s synonyms and chemical isomers. Results: Only five relevant publications emerged from the literature search, with most of the available data on body building websites and fora. Since 2015, Octodrine has been advertised online as “the next big thing” and “the god of stimulants,” with captivating marketing strategies directed at athletes and a wider cohort of users. Reported side-effects include hypertension, dyspnoea and hyperthermia. Conclusions: The uncontrolled use of Octodrine, its physiological and psychoactive effects raise serious health implications with possible impact on athletes and doping practices. This new phenomenon needs to be thoroughly studied and monitored. MDPI 2018-02-20 /pmc/articles/PMC5836053/ /pubmed/29461475 http://dx.doi.org/10.3390/brainsci8020034 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Catalani, Valeria
Prilutskaya, Mariya
Al-Imam, Ahmed
Marrinan, Shanna
Elgharably, Yasmine
Zloh, Mire
Martinotti, Giovanni
Chilcott, Robert
Corazza, Ornella
Octodrine: New Questions and Challenges in Sport Supplements
title Octodrine: New Questions and Challenges in Sport Supplements
title_full Octodrine: New Questions and Challenges in Sport Supplements
title_fullStr Octodrine: New Questions and Challenges in Sport Supplements
title_full_unstemmed Octodrine: New Questions and Challenges in Sport Supplements
title_short Octodrine: New Questions and Challenges in Sport Supplements
title_sort octodrine: new questions and challenges in sport supplements
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836053/
https://www.ncbi.nlm.nih.gov/pubmed/29461475
http://dx.doi.org/10.3390/brainsci8020034
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