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Volumetric Modulated Arc (Radio) Therapy in Pets Treatment: The “La Cittadina Fondazione” Experience

Volumetric Modulated Arc Therapy (VMAT) is a modern technique, widely used in human radiotherapy, which allows a high dose to be delivered to tumor volumes and low doses to the surrounding organs at risk (OAR). Veterinary clinics takes advantage of this feature due to the small target volumes and di...

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Autores principales: Dolera, Mario, Malfassi, Luca, Carrara, Nancy, Finesso, Sara, Marcarini, Silvia, Mazza, Giovanni, Pavesi, Simone, Sala, Massimo, Urso, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836062/
https://www.ncbi.nlm.nih.gov/pubmed/29364837
http://dx.doi.org/10.3390/cancers10020030
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author Dolera, Mario
Malfassi, Luca
Carrara, Nancy
Finesso, Sara
Marcarini, Silvia
Mazza, Giovanni
Pavesi, Simone
Sala, Massimo
Urso, Gaetano
author_facet Dolera, Mario
Malfassi, Luca
Carrara, Nancy
Finesso, Sara
Marcarini, Silvia
Mazza, Giovanni
Pavesi, Simone
Sala, Massimo
Urso, Gaetano
author_sort Dolera, Mario
collection PubMed
description Volumetric Modulated Arc Therapy (VMAT) is a modern technique, widely used in human radiotherapy, which allows a high dose to be delivered to tumor volumes and low doses to the surrounding organs at risk (OAR). Veterinary clinics takes advantage of this feature due to the small target volumes and distances between the target and the OAR. Sparing the OAR permits dose escalation, and hypofractionation regimens reduce the number of treatment sessions with a simpler manageability in the veterinary field. Multimodal volumes definition is mandatory for the small volumes involved and a positioning device precisely reproducible with a setup confirmation is needed before each session for avoiding missing the target. Additionally, the elaborate treatment plan must pursue hard constraints and objectives, and its feasibility must be evaluated with a per patient quality control. The aim of this work is to report results with regard to brain meningiomas and gliomas, trigeminal nerve tumors, brachial plexus tumors, adrenal tumors with vascular invasion and rabbit thymomas, in comparison with literature to determine if VMAT is a safe and viable alternative to surgery or chemotherapy alone, or as an adjuvant therapy in pets.
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spelling pubmed-58360622018-03-07 Volumetric Modulated Arc (Radio) Therapy in Pets Treatment: The “La Cittadina Fondazione” Experience Dolera, Mario Malfassi, Luca Carrara, Nancy Finesso, Sara Marcarini, Silvia Mazza, Giovanni Pavesi, Simone Sala, Massimo Urso, Gaetano Cancers (Basel) Review Volumetric Modulated Arc Therapy (VMAT) is a modern technique, widely used in human radiotherapy, which allows a high dose to be delivered to tumor volumes and low doses to the surrounding organs at risk (OAR). Veterinary clinics takes advantage of this feature due to the small target volumes and distances between the target and the OAR. Sparing the OAR permits dose escalation, and hypofractionation regimens reduce the number of treatment sessions with a simpler manageability in the veterinary field. Multimodal volumes definition is mandatory for the small volumes involved and a positioning device precisely reproducible with a setup confirmation is needed before each session for avoiding missing the target. Additionally, the elaborate treatment plan must pursue hard constraints and objectives, and its feasibility must be evaluated with a per patient quality control. The aim of this work is to report results with regard to brain meningiomas and gliomas, trigeminal nerve tumors, brachial plexus tumors, adrenal tumors with vascular invasion and rabbit thymomas, in comparison with literature to determine if VMAT is a safe and viable alternative to surgery or chemotherapy alone, or as an adjuvant therapy in pets. MDPI 2018-01-24 /pmc/articles/PMC5836062/ /pubmed/29364837 http://dx.doi.org/10.3390/cancers10020030 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dolera, Mario
Malfassi, Luca
Carrara, Nancy
Finesso, Sara
Marcarini, Silvia
Mazza, Giovanni
Pavesi, Simone
Sala, Massimo
Urso, Gaetano
Volumetric Modulated Arc (Radio) Therapy in Pets Treatment: The “La Cittadina Fondazione” Experience
title Volumetric Modulated Arc (Radio) Therapy in Pets Treatment: The “La Cittadina Fondazione” Experience
title_full Volumetric Modulated Arc (Radio) Therapy in Pets Treatment: The “La Cittadina Fondazione” Experience
title_fullStr Volumetric Modulated Arc (Radio) Therapy in Pets Treatment: The “La Cittadina Fondazione” Experience
title_full_unstemmed Volumetric Modulated Arc (Radio) Therapy in Pets Treatment: The “La Cittadina Fondazione” Experience
title_short Volumetric Modulated Arc (Radio) Therapy in Pets Treatment: The “La Cittadina Fondazione” Experience
title_sort volumetric modulated arc (radio) therapy in pets treatment: the “la cittadina fondazione” experience
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836062/
https://www.ncbi.nlm.nih.gov/pubmed/29364837
http://dx.doi.org/10.3390/cancers10020030
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