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Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond

In addition to the structural and scaffolding role, the extracellular matrix (ECM) is emerging as a hub for biomechanical signal transduction that is frequently relayed to intracellular sensors to regulate diverse cellular processes. At a macroscopic scale, matrix rigidity confers long-ranging effec...

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Detalles Bibliográficos
Autores principales: Chakraborty, Sayan, Hong, Wanjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836077/
https://www.ncbi.nlm.nih.gov/pubmed/29415512
http://dx.doi.org/10.3390/cancers10020045
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author Chakraborty, Sayan
Hong, Wanjin
author_facet Chakraborty, Sayan
Hong, Wanjin
author_sort Chakraborty, Sayan
collection PubMed
description In addition to the structural and scaffolding role, the extracellular matrix (ECM) is emerging as a hub for biomechanical signal transduction that is frequently relayed to intracellular sensors to regulate diverse cellular processes. At a macroscopic scale, matrix rigidity confers long-ranging effects contributing towards tissue fibrosis and cancer. The transcriptional co-activators YAP/TAZ, better known as the converging effectors of the Hippo pathway, are widely recognized for their new role as nuclear mechanosensors during organ homeostasis and cancer. Still, how YAP/TAZ senses these “stiffness cues” from the ECM remains enigmatic. Here, we highlight the recent perspectives on the role of agrin in mechanosignaling from the ECM via antagonizing the Hippo pathway to activate YAP/TAZ in the contexts of cancer, neuromuscular junctions, and cardiac regeneration.
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spelling pubmed-58360772018-03-07 Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond Chakraborty, Sayan Hong, Wanjin Cancers (Basel) Review In addition to the structural and scaffolding role, the extracellular matrix (ECM) is emerging as a hub for biomechanical signal transduction that is frequently relayed to intracellular sensors to regulate diverse cellular processes. At a macroscopic scale, matrix rigidity confers long-ranging effects contributing towards tissue fibrosis and cancer. The transcriptional co-activators YAP/TAZ, better known as the converging effectors of the Hippo pathway, are widely recognized for their new role as nuclear mechanosensors during organ homeostasis and cancer. Still, how YAP/TAZ senses these “stiffness cues” from the ECM remains enigmatic. Here, we highlight the recent perspectives on the role of agrin in mechanosignaling from the ECM via antagonizing the Hippo pathway to activate YAP/TAZ in the contexts of cancer, neuromuscular junctions, and cardiac regeneration. MDPI 2018-02-06 /pmc/articles/PMC5836077/ /pubmed/29415512 http://dx.doi.org/10.3390/cancers10020045 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chakraborty, Sayan
Hong, Wanjin
Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond
title Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond
title_full Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond
title_fullStr Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond
title_full_unstemmed Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond
title_short Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond
title_sort linking extracellular matrix agrin to the hippo pathway in liver cancer and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836077/
https://www.ncbi.nlm.nih.gov/pubmed/29415512
http://dx.doi.org/10.3390/cancers10020045
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