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Intracranial Leptomeningeal Carcinomatosis: A Diagnostic Study with (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography
Leptomeningeal carcinomatosis (LC) diagnosis is based on cerebrospinal fluid (CSF) cytological analysis and contrast-enhanced magnetic resonance imaging (MRI); however, low sensitivity was evidenced in some cases delaying prompt and adequate treatments. Brain (18)F-fluorodeoxyglucose positron emissi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836194/ https://www.ncbi.nlm.nih.gov/pubmed/29515424 http://dx.doi.org/10.1159/000486710 |
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author | Nuvoli, Susanna Contu, Silvia Pung, Bi Llie Joy Solinas, Patrizia Madeddu, Giuseppe Spanu, Angela |
author_facet | Nuvoli, Susanna Contu, Silvia Pung, Bi Llie Joy Solinas, Patrizia Madeddu, Giuseppe Spanu, Angela |
author_sort | Nuvoli, Susanna |
collection | PubMed |
description | Leptomeningeal carcinomatosis (LC) diagnosis is based on cerebrospinal fluid (CSF) cytological analysis and contrast-enhanced magnetic resonance imaging (MRI); however, low sensitivity was evidenced in some cases delaying prompt and adequate treatments. Brain (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) was also employed in doubtful cases. We retrospectively described 4 suspected LC cases with uncertain or undetectable MRI and initially negative CSF cytology. Whole-body (WB) and brain (18)F-FDG PET/computed tomography (CT) were used, the latter showing intracranial tracer uptakes suspected for LC in 3/4 cases. In 2 of these 3 cases, WB scan also evidenced spinal cord lesion and pulmonary tumor, respectively, while both procedures were true negative in the fourth case. CSF cytology became positive after repeated exams in the 3 PET/CT-positive cases. In 1 of these 3 patients, it was also confirmed at MRI, while it stayed negative in the remaining PET/CT-negative case with uncertain MRI. (18)F-FDG PET/CT could be a useful supportive diagnostic tool in doubtful intracranial and spinal LC. |
format | Online Article Text |
id | pubmed-5836194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-58361942018-03-07 Intracranial Leptomeningeal Carcinomatosis: A Diagnostic Study with (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Nuvoli, Susanna Contu, Silvia Pung, Bi Llie Joy Solinas, Patrizia Madeddu, Giuseppe Spanu, Angela Case Rep Neurol Case Report Leptomeningeal carcinomatosis (LC) diagnosis is based on cerebrospinal fluid (CSF) cytological analysis and contrast-enhanced magnetic resonance imaging (MRI); however, low sensitivity was evidenced in some cases delaying prompt and adequate treatments. Brain (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) was also employed in doubtful cases. We retrospectively described 4 suspected LC cases with uncertain or undetectable MRI and initially negative CSF cytology. Whole-body (WB) and brain (18)F-FDG PET/computed tomography (CT) were used, the latter showing intracranial tracer uptakes suspected for LC in 3/4 cases. In 2 of these 3 cases, WB scan also evidenced spinal cord lesion and pulmonary tumor, respectively, while both procedures were true negative in the fourth case. CSF cytology became positive after repeated exams in the 3 PET/CT-positive cases. In 1 of these 3 patients, it was also confirmed at MRI, while it stayed negative in the remaining PET/CT-negative case with uncertain MRI. (18)F-FDG PET/CT could be a useful supportive diagnostic tool in doubtful intracranial and spinal LC. S. Karger AG 2018-02-09 /pmc/articles/PMC5836194/ /pubmed/29515424 http://dx.doi.org/10.1159/000486710 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Nuvoli, Susanna Contu, Silvia Pung, Bi Llie Joy Solinas, Patrizia Madeddu, Giuseppe Spanu, Angela Intracranial Leptomeningeal Carcinomatosis: A Diagnostic Study with (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography |
title | Intracranial Leptomeningeal Carcinomatosis: A Diagnostic Study with (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography |
title_full | Intracranial Leptomeningeal Carcinomatosis: A Diagnostic Study with (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography |
title_fullStr | Intracranial Leptomeningeal Carcinomatosis: A Diagnostic Study with (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography |
title_full_unstemmed | Intracranial Leptomeningeal Carcinomatosis: A Diagnostic Study with (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography |
title_short | Intracranial Leptomeningeal Carcinomatosis: A Diagnostic Study with (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography |
title_sort | intracranial leptomeningeal carcinomatosis: a diagnostic study with (18)f-fluorodeoxyglucose positron emission tomography/computed tomography |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836194/ https://www.ncbi.nlm.nih.gov/pubmed/29515424 http://dx.doi.org/10.1159/000486710 |
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