Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod

Simultaneous or sequential, planned administration of ipilimumab could significantly enhance the antitumor effects of nivolumab in advanced melanoma patients. On the other hand, the efficacy of ipilimumab for nivolumab-resistant advanced melanoma is extremely poor. Therefore, additional supportive t...

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Autores principales: Fujimura, Taku, Kambayashi, Yumi, Sato, Yota, Tanita, Kayo, Furudate, Sadanori, Tsukada, Akira, Tono, Hisayuki, Hashimoto, Akira, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836202/
https://www.ncbi.nlm.nih.gov/pubmed/29515401
http://dx.doi.org/10.1159/000485612
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author Fujimura, Taku
Kambayashi, Yumi
Sato, Yota
Tanita, Kayo
Furudate, Sadanori
Tsukada, Akira
Tono, Hisayuki
Hashimoto, Akira
Aiba, Setsuya
author_facet Fujimura, Taku
Kambayashi, Yumi
Sato, Yota
Tanita, Kayo
Furudate, Sadanori
Tsukada, Akira
Tono, Hisayuki
Hashimoto, Akira
Aiba, Setsuya
author_sort Fujimura, Taku
collection PubMed
description Simultaneous or sequential, planned administration of ipilimumab could significantly enhance the antitumor effects of nivolumab in advanced melanoma patients. On the other hand, the efficacy of ipilimumab for nivolumab-resistant advanced melanoma is extremely poor. Therefore, additional supportive therapy for anti-PD-1 antibody therapy-resistant advanced melanoma has been widely investigated. In this report, we describe a case of multiple in-transit melanomas developing in a nivolumab-resistant patient successfully treated with ipilimumab in combination with imiquimod. Our present case suggested a possible therapy for nivolumab-resistant multiple in-transit melanomas using ipilimumab in combination with topical imiquimod.
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spelling pubmed-58362022018-03-07 Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod Fujimura, Taku Kambayashi, Yumi Sato, Yota Tanita, Kayo Furudate, Sadanori Tsukada, Akira Tono, Hisayuki Hashimoto, Akira Aiba, Setsuya Case Rep Oncol Case Report Simultaneous or sequential, planned administration of ipilimumab could significantly enhance the antitumor effects of nivolumab in advanced melanoma patients. On the other hand, the efficacy of ipilimumab for nivolumab-resistant advanced melanoma is extremely poor. Therefore, additional supportive therapy for anti-PD-1 antibody therapy-resistant advanced melanoma has been widely investigated. In this report, we describe a case of multiple in-transit melanomas developing in a nivolumab-resistant patient successfully treated with ipilimumab in combination with imiquimod. Our present case suggested a possible therapy for nivolumab-resistant multiple in-transit melanomas using ipilimumab in combination with topical imiquimod. S. Karger AG 2018-01-04 /pmc/articles/PMC5836202/ /pubmed/29515401 http://dx.doi.org/10.1159/000485612 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Fujimura, Taku
Kambayashi, Yumi
Sato, Yota
Tanita, Kayo
Furudate, Sadanori
Tsukada, Akira
Tono, Hisayuki
Hashimoto, Akira
Aiba, Setsuya
Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod
title Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod
title_full Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod
title_fullStr Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod
title_full_unstemmed Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod
title_short Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod
title_sort successful treatment of nivolumab-resistant multiple in-transit melanomas with ipilimumab and topical imiquimod
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836202/
https://www.ncbi.nlm.nih.gov/pubmed/29515401
http://dx.doi.org/10.1159/000485612
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