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Verbal or Visual Memory Score and Regional Cerebral Blood Flow in Alzheimer Disease
OBJECTIVE: Among many cognitive function deficits, memory impairment is an initial and cardinal symptom in Alzheimer disease (AD). In most cases, verbal and visual memory scores correlate highly, but in some cases the deficit of verbal or visual memory is very different from that of the other memory...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836286/ https://www.ncbi.nlm.nih.gov/pubmed/29515618 http://dx.doi.org/10.1159/000486093 |
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author | Hayashi, Satoshi Terada, Seishi Oshima, Etsuko Sato, Shuhei Kurisu, Kairi Takenoshita, Shintaro Yokota, Osamu Yamada, Norihito |
author_facet | Hayashi, Satoshi Terada, Seishi Oshima, Etsuko Sato, Shuhei Kurisu, Kairi Takenoshita, Shintaro Yokota, Osamu Yamada, Norihito |
author_sort | Hayashi, Satoshi |
collection | PubMed |
description | OBJECTIVE: Among many cognitive function deficits, memory impairment is an initial and cardinal symptom in Alzheimer disease (AD). In most cases, verbal and visual memory scores correlate highly, but in some cases the deficit of verbal or visual memory is very different from that of the other memory. In this study, we examined the neural substrates of verbal and visual memory in patients with AD. METHODS: One hundred eighty-eight consecutive patients with AD were recruited from outpatient units. Verbal and visual memory scores were evaluated using the Wechsler Memory Scale – revised. The patients underwent brain SPECT with (99m)Tc-ethylcysteinate dimer. RESULTS: After removing the effects of age, sex, education, and Mini-Mental State Examination scores, correlation analysis showed a significant correlation of verbal memory scores to regional cerebral blood flow (rCBF) in the bilateral cingulate gyrus and left precuneus. Similarly, a significant correlation of visual memory scores to rCBF was found in the right precuneus and right cingulate gyrus. CONCLUSION: The posterior medial cortices (PMC) are very important areas in episodic memory among patients with mild AD. Verbal memory is more closely related to the both sides of the PMC, while visual memory is more closely related to the right PMC. |
format | Online Article Text |
id | pubmed-5836286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-58362862018-03-07 Verbal or Visual Memory Score and Regional Cerebral Blood Flow in Alzheimer Disease Hayashi, Satoshi Terada, Seishi Oshima, Etsuko Sato, Shuhei Kurisu, Kairi Takenoshita, Shintaro Yokota, Osamu Yamada, Norihito Dement Geriatr Cogn Dis Extra Original Research Article OBJECTIVE: Among many cognitive function deficits, memory impairment is an initial and cardinal symptom in Alzheimer disease (AD). In most cases, verbal and visual memory scores correlate highly, but in some cases the deficit of verbal or visual memory is very different from that of the other memory. In this study, we examined the neural substrates of verbal and visual memory in patients with AD. METHODS: One hundred eighty-eight consecutive patients with AD were recruited from outpatient units. Verbal and visual memory scores were evaluated using the Wechsler Memory Scale – revised. The patients underwent brain SPECT with (99m)Tc-ethylcysteinate dimer. RESULTS: After removing the effects of age, sex, education, and Mini-Mental State Examination scores, correlation analysis showed a significant correlation of verbal memory scores to regional cerebral blood flow (rCBF) in the bilateral cingulate gyrus and left precuneus. Similarly, a significant correlation of visual memory scores to rCBF was found in the right precuneus and right cingulate gyrus. CONCLUSION: The posterior medial cortices (PMC) are very important areas in episodic memory among patients with mild AD. Verbal memory is more closely related to the both sides of the PMC, while visual memory is more closely related to the right PMC. S. Karger AG 2018-01-23 /pmc/articles/PMC5836286/ /pubmed/29515618 http://dx.doi.org/10.1159/000486093 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. |
spellingShingle | Original Research Article Hayashi, Satoshi Terada, Seishi Oshima, Etsuko Sato, Shuhei Kurisu, Kairi Takenoshita, Shintaro Yokota, Osamu Yamada, Norihito Verbal or Visual Memory Score and Regional Cerebral Blood Flow in Alzheimer Disease |
title | Verbal or Visual Memory Score and Regional Cerebral Blood Flow in Alzheimer Disease |
title_full | Verbal or Visual Memory Score and Regional Cerebral Blood Flow in Alzheimer Disease |
title_fullStr | Verbal or Visual Memory Score and Regional Cerebral Blood Flow in Alzheimer Disease |
title_full_unstemmed | Verbal or Visual Memory Score and Regional Cerebral Blood Flow in Alzheimer Disease |
title_short | Verbal or Visual Memory Score and Regional Cerebral Blood Flow in Alzheimer Disease |
title_sort | verbal or visual memory score and regional cerebral blood flow in alzheimer disease |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836286/ https://www.ncbi.nlm.nih.gov/pubmed/29515618 http://dx.doi.org/10.1159/000486093 |
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