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Detection of Proteome Diversity Resulted from Alternative Splicing is Limited by Trypsin Cleavage Specificity

Alternative splicing dramatically increases transcriptome complexity but its contribution to proteome diversity remains controversial. Exon-exon junction spanning peptides provide direct evidence for the translation of specific splice isoforms and are critical for delineating protein isoform complex...

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Detalles Bibliográficos
Autores principales:	Wang, Xiaojing, Codreanu, Simona G., Wen, Bo, Li, Kai, Chambers, Matthew C., Liebler, Daniel C., Zhang, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836368/ https://www.ncbi.nlm.nih.gov/pubmed/29222161 http://dx.doi.org/10.1074/mcp.RA117.000155

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