Increased Prevalence of Polyneuropathy in Parkinson’s Disease Patients: An Observational Study

BACKGROUND: The independent contribution of levodopa exposure and Parkinson’s disease (PD) to the risk of polyneuropathy is not established. OBJECTIVE: This study investigated whether patients with newly diagnosed PD without previous exposure to antiparkinsonian drugs have higher prevalence of polyn...

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Detalles Bibliográficos
Autores principales: Conradt, Christian, Guo, Dianlin, Miclea, Anca, Nisslein, Thomas, Ismail, Chaim, Chatamra, Krai, Andersohn, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2018
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836410/
https://www.ncbi.nlm.nih.gov/pubmed/29154292
http://dx.doi.org/10.3233/JPD-161057
Descripción
Sumario:BACKGROUND: The independent contribution of levodopa exposure and Parkinson’s disease (PD) to the risk of polyneuropathy is not established. OBJECTIVE: This study investigated whether patients with newly diagnosed PD without previous exposure to antiparkinsonian drugs have higher prevalence of polyneuropathy than the general population. METHODS: Using the UK General Practice Research Database, presence of polyneuropathy in the previous 3 years was assessed. RESULTS: Of 5089 PD patients and 19,897 controls, polyneuropathy was confirmed in 15 PD patients (0.29% ) and 24 controls (0.12% ). Polyneuropathy prevalence was 2.4-fold higher in PD patients than controls. CONCLUSIONS: In this observational study, PD patients had a higher prevalence of preexisting polyneuropathy that cannot be explained by adverse effects of antiparkinsonian drugs.

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