Increased Prevalence of Polyneuropathy in Parkinson’s Disease Patients: An Observational Study

BACKGROUND: The independent contribution of levodopa exposure and Parkinson’s disease (PD) to the risk of polyneuropathy is not established. OBJECTIVE: This study investigated whether patients with newly diagnosed PD without previous exposure to antiparkinsonian drugs have higher prevalence of polyn...

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Autores principales: Conradt, Christian, Guo, Dianlin, Miclea, Anca, Nisslein, Thomas, Ismail, Chaim, Chatamra, Krai, Andersohn, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2018
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836410/
https://www.ncbi.nlm.nih.gov/pubmed/29154292
http://dx.doi.org/10.3233/JPD-161057
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author Conradt, Christian
Guo, Dianlin
Miclea, Anca
Nisslein, Thomas
Ismail, Chaim
Chatamra, Krai
Andersohn, Frank
author_facet Conradt, Christian
Guo, Dianlin
Miclea, Anca
Nisslein, Thomas
Ismail, Chaim
Chatamra, Krai
Andersohn, Frank
author_sort Conradt, Christian
collection PubMed
description BACKGROUND: The independent contribution of levodopa exposure and Parkinson’s disease (PD) to the risk of polyneuropathy is not established. OBJECTIVE: This study investigated whether patients with newly diagnosed PD without previous exposure to antiparkinsonian drugs have higher prevalence of polyneuropathy than the general population. METHODS: Using the UK General Practice Research Database, presence of polyneuropathy in the previous 3 years was assessed. RESULTS: Of 5089 PD patients and 19,897 controls, polyneuropathy was confirmed in 15 PD patients (0.29% ) and 24 controls (0.12% ). Polyneuropathy prevalence was 2.4-fold higher in PD patients than controls. CONCLUSIONS: In this observational study, PD patients had a higher prevalence of preexisting polyneuropathy that cannot be explained by adverse effects of antiparkinsonian drugs.
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spelling pubmed-58364102018-03-07 Increased Prevalence of Polyneuropathy in Parkinson’s Disease Patients: An Observational Study Conradt, Christian Guo, Dianlin Miclea, Anca Nisslein, Thomas Ismail, Chaim Chatamra, Krai Andersohn, Frank J Parkinsons Dis Research Report BACKGROUND: The independent contribution of levodopa exposure and Parkinson’s disease (PD) to the risk of polyneuropathy is not established. OBJECTIVE: This study investigated whether patients with newly diagnosed PD without previous exposure to antiparkinsonian drugs have higher prevalence of polyneuropathy than the general population. METHODS: Using the UK General Practice Research Database, presence of polyneuropathy in the previous 3 years was assessed. RESULTS: Of 5089 PD patients and 19,897 controls, polyneuropathy was confirmed in 15 PD patients (0.29% ) and 24 controls (0.12% ). Polyneuropathy prevalence was 2.4-fold higher in PD patients than controls. CONCLUSIONS: In this observational study, PD patients had a higher prevalence of preexisting polyneuropathy that cannot be explained by adverse effects of antiparkinsonian drugs. IOS Press 2018-02-17 /pmc/articles/PMC5836410/ /pubmed/29154292 http://dx.doi.org/10.3233/JPD-161057 Text en © 2018 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Report
Conradt, Christian
Guo, Dianlin
Miclea, Anca
Nisslein, Thomas
Ismail, Chaim
Chatamra, Krai
Andersohn, Frank
Increased Prevalence of Polyneuropathy in Parkinson’s Disease Patients: An Observational Study
title Increased Prevalence of Polyneuropathy in Parkinson’s Disease Patients: An Observational Study
title_full Increased Prevalence of Polyneuropathy in Parkinson’s Disease Patients: An Observational Study
title_fullStr Increased Prevalence of Polyneuropathy in Parkinson’s Disease Patients: An Observational Study
title_full_unstemmed Increased Prevalence of Polyneuropathy in Parkinson’s Disease Patients: An Observational Study
title_short Increased Prevalence of Polyneuropathy in Parkinson’s Disease Patients: An Observational Study
title_sort increased prevalence of polyneuropathy in parkinson’s disease patients: an observational study
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836410/
https://www.ncbi.nlm.nih.gov/pubmed/29154292
http://dx.doi.org/10.3233/JPD-161057
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