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DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
BACKGROUND: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG islan...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836434/ https://www.ncbi.nlm.nih.gov/pubmed/29515676 http://dx.doi.org/10.1186/s13148-018-0466-3 |
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author | Borssén, Magnus Nordlund, Jessica Haider, Zahra Landfors, Mattias Larsson, Pär Kanerva, Jukka Schmiegelow, Kjeld Flaegstad, Trond Jónsson, Ólafur Gísli Frost, Britt-Marie Palle, Josefine Forestier, Erik Heyman, Mats Hultdin, Magnus Lönnerholm, Gudmar Degerman, Sofie |
author_facet | Borssén, Magnus Nordlund, Jessica Haider, Zahra Landfors, Mattias Larsson, Pär Kanerva, Jukka Schmiegelow, Kjeld Flaegstad, Trond Jónsson, Ólafur Gísli Frost, Britt-Marie Palle, Josefine Forestier, Erik Heyman, Mats Hultdin, Magnus Lönnerholm, Gudmar Degerman, Sofie |
author_sort | Borssén, Magnus |
collection | PubMed |
description | BACKGROUND: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. METHODS: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1–18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. RESULTS: Among the 137 patients that later relapsed, patients with a CIMP− profile (n = 42) at initial diagnosis had an inferior overall survival (pOS(5years) 33%) compared to CIMP+ patients (n = 95, pOS(5years) 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. CONCLUSION: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13148-018-0466-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5836434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-58364342018-03-07 DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia Borssén, Magnus Nordlund, Jessica Haider, Zahra Landfors, Mattias Larsson, Pär Kanerva, Jukka Schmiegelow, Kjeld Flaegstad, Trond Jónsson, Ólafur Gísli Frost, Britt-Marie Palle, Josefine Forestier, Erik Heyman, Mats Hultdin, Magnus Lönnerholm, Gudmar Degerman, Sofie Clin Epigenetics Short Report BACKGROUND: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. METHODS: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1–18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. RESULTS: Among the 137 patients that later relapsed, patients with a CIMP− profile (n = 42) at initial diagnosis had an inferior overall survival (pOS(5years) 33%) compared to CIMP+ patients (n = 95, pOS(5years) 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. CONCLUSION: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13148-018-0466-3) contains supplementary material, which is available to authorized users. BioMed Central 2018-03-05 /pmc/articles/PMC5836434/ /pubmed/29515676 http://dx.doi.org/10.1186/s13148-018-0466-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Short Report Borssén, Magnus Nordlund, Jessica Haider, Zahra Landfors, Mattias Larsson, Pär Kanerva, Jukka Schmiegelow, Kjeld Flaegstad, Trond Jónsson, Ólafur Gísli Frost, Britt-Marie Palle, Josefine Forestier, Erik Heyman, Mats Hultdin, Magnus Lönnerholm, Gudmar Degerman, Sofie DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia |
title | DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia |
title_full | DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia |
title_fullStr | DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia |
title_full_unstemmed | DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia |
title_short | DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia |
title_sort | dna methylation holds prognostic information in relapsed precursor b-cell acute lymphoblastic leukemia |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836434/ https://www.ncbi.nlm.nih.gov/pubmed/29515676 http://dx.doi.org/10.1186/s13148-018-0466-3 |
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