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Lipid profiles in French West Indies sickle cell disease cohorts, and their general population

BACKGROUND: The pathophysiology of sickle cell disease (SCD) and the variability of its clinical expression remain not fully understood, whether within or between different SCD genotypes. Recent studies have reported associations between lipid levels and several SCD complications. If lipid levels ha...

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Autores principales: Lalanne-Mistrih, Marie-Laure, Connes, Philippe, Lamarre, Yann, Lemonne, Nathalie, Hardy-Dessources, Marie-Dominique, Tarer, Vanessa, Etienne-Julan, Maryse, Mougenel, Dominique, Tressières, Benoît, Romana, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836466/
https://www.ncbi.nlm.nih.gov/pubmed/29506549
http://dx.doi.org/10.1186/s12944-018-0689-5
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author Lalanne-Mistrih, Marie-Laure
Connes, Philippe
Lamarre, Yann
Lemonne, Nathalie
Hardy-Dessources, Marie-Dominique
Tarer, Vanessa
Etienne-Julan, Maryse
Mougenel, Dominique
Tressières, Benoît
Romana, Marc
author_facet Lalanne-Mistrih, Marie-Laure
Connes, Philippe
Lamarre, Yann
Lemonne, Nathalie
Hardy-Dessources, Marie-Dominique
Tarer, Vanessa
Etienne-Julan, Maryse
Mougenel, Dominique
Tressières, Benoît
Romana, Marc
author_sort Lalanne-Mistrih, Marie-Laure
collection PubMed
description BACKGROUND: The pathophysiology of sickle cell disease (SCD) and the variability of its clinical expression remain not fully understood, whether within or between different SCD genotypes. Recent studies have reported associations between lipid levels and several SCD complications. If lipid levels have been previously described as low in sickle cell anemia (SCA), few data have been provided for sickle cell SC disease (SCC). We designed our epidemiological study to isolate lipid levels and profiles by genotype in Guadeloupian cohorts of SCA and SCC adult patients, at steady state. We compared SCD lipid levels with those of the Guadeloupian general population (GGP), and analyzed potential associations between lipid levels and SCD complications (vaso-occlusive crises, acute chest syndrome and osteonecrosis). METHODS: Lipids, apolipoproteins, biological variables and anthropometric evaluation, were collected at steady state from medical files for 62 SCC and 97 SCA adult patients. Clinical SCD complications were collected from the clinical files. Analysis was conducted by genotype for all variables. RESULTS: Different SCC and SCA lipid profiles, both distinct from their GGP’s, were identified. Compared to SCC and GGP, higher triglyceride (TG) levels were observed in SCA patients, independent of hydroxyurea, hemolysis, gender, age, body mass index (BMI), abdominal obesity and clinical nutritional status. Our survey highlights also subsequent anthropometrical phenotypes, with an over-representation of abdominal obesity with normal BMI in SCA patients, and affecting almost exclusively females in both genotypes. Moreover, more frequent positive history of acute chest syndrome (ACS) was observed in SCA patients with TG level higher than 1.50 g/l, and of osteonecrosis in SCC patients having non high-density lipoprotein-cholesterol level (Non HDL-C) higher than 1.30 g/l. CONCLUSIONS: This study reveals that SCA and SCC patients exhibit distinct lipid profiles and suggests that high TG and Non HDL-C levels are associated with past histories of ACS and osteonecrosis in SCA and SCC patients, respectively.
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spelling pubmed-58364662018-03-07 Lipid profiles in French West Indies sickle cell disease cohorts, and their general population Lalanne-Mistrih, Marie-Laure Connes, Philippe Lamarre, Yann Lemonne, Nathalie Hardy-Dessources, Marie-Dominique Tarer, Vanessa Etienne-Julan, Maryse Mougenel, Dominique Tressières, Benoît Romana, Marc Lipids Health Dis Research BACKGROUND: The pathophysiology of sickle cell disease (SCD) and the variability of its clinical expression remain not fully understood, whether within or between different SCD genotypes. Recent studies have reported associations between lipid levels and several SCD complications. If lipid levels have been previously described as low in sickle cell anemia (SCA), few data have been provided for sickle cell SC disease (SCC). We designed our epidemiological study to isolate lipid levels and profiles by genotype in Guadeloupian cohorts of SCA and SCC adult patients, at steady state. We compared SCD lipid levels with those of the Guadeloupian general population (GGP), and analyzed potential associations between lipid levels and SCD complications (vaso-occlusive crises, acute chest syndrome and osteonecrosis). METHODS: Lipids, apolipoproteins, biological variables and anthropometric evaluation, were collected at steady state from medical files for 62 SCC and 97 SCA adult patients. Clinical SCD complications were collected from the clinical files. Analysis was conducted by genotype for all variables. RESULTS: Different SCC and SCA lipid profiles, both distinct from their GGP’s, were identified. Compared to SCC and GGP, higher triglyceride (TG) levels were observed in SCA patients, independent of hydroxyurea, hemolysis, gender, age, body mass index (BMI), abdominal obesity and clinical nutritional status. Our survey highlights also subsequent anthropometrical phenotypes, with an over-representation of abdominal obesity with normal BMI in SCA patients, and affecting almost exclusively females in both genotypes. Moreover, more frequent positive history of acute chest syndrome (ACS) was observed in SCA patients with TG level higher than 1.50 g/l, and of osteonecrosis in SCC patients having non high-density lipoprotein-cholesterol level (Non HDL-C) higher than 1.30 g/l. CONCLUSIONS: This study reveals that SCA and SCC patients exhibit distinct lipid profiles and suggests that high TG and Non HDL-C levels are associated with past histories of ACS and osteonecrosis in SCA and SCC patients, respectively. BioMed Central 2018-03-05 /pmc/articles/PMC5836466/ /pubmed/29506549 http://dx.doi.org/10.1186/s12944-018-0689-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Lalanne-Mistrih, Marie-Laure
Connes, Philippe
Lamarre, Yann
Lemonne, Nathalie
Hardy-Dessources, Marie-Dominique
Tarer, Vanessa
Etienne-Julan, Maryse
Mougenel, Dominique
Tressières, Benoît
Romana, Marc
Lipid profiles in French West Indies sickle cell disease cohorts, and their general population
title Lipid profiles in French West Indies sickle cell disease cohorts, and their general population
title_full Lipid profiles in French West Indies sickle cell disease cohorts, and their general population
title_fullStr Lipid profiles in French West Indies sickle cell disease cohorts, and their general population
title_full_unstemmed Lipid profiles in French West Indies sickle cell disease cohorts, and their general population
title_short Lipid profiles in French West Indies sickle cell disease cohorts, and their general population
title_sort lipid profiles in french west indies sickle cell disease cohorts, and their general population
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836466/
https://www.ncbi.nlm.nih.gov/pubmed/29506549
http://dx.doi.org/10.1186/s12944-018-0689-5
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