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Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations
Aplastic anemia is a hematologic condition occasionally presenting during pregnancy. This pathological process is associated with significant maternal and neonatal morbidity and mortality. Obstetric and anesthetic management is challenging, and treatment requires a coordinated effort by an interdisc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836687/ https://www.ncbi.nlm.nih.gov/pubmed/29535558 http://dx.doi.org/10.2147/IJWH.S149683 |
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author | Riveros-Perez, Efrain Hermesch, Amy C Barbour, Linda A Hawkins, Joy L |
author_facet | Riveros-Perez, Efrain Hermesch, Amy C Barbour, Linda A Hawkins, Joy L |
author_sort | Riveros-Perez, Efrain |
collection | PubMed |
description | Aplastic anemia is a hematologic condition occasionally presenting during pregnancy. This pathological process is associated with significant maternal and neonatal morbidity and mortality. Obstetric and anesthetic management is challenging, and treatment requires a coordinated effort by an interdisciplinary team, in order to provide safe care to these patients. In this review, we describe the current state of the literature as it applies to the complexity of aplastic anemia in pregnancy, focusing on pathophysiologic aspects of the disease in pregnancy, as well as relevant obstetric and anesthetic considerations necessary to treat this challenging problem. A multidisciplinary-team approach to the management of aplastic anemia in pregnancy is necessary to coordinate prenatal care, optimize maternofetal outcomes, and plan peripartum interventions. Conservative transfusion management is critical to prevent alloimmunization. Although a safe threshold-platelet count for neuraxial anesthesia has not been established, selection of anesthetic technique must be evaluated on a case-to-case basis. |
format | Online Article Text |
id | pubmed-5836687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58366872018-03-13 Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations Riveros-Perez, Efrain Hermesch, Amy C Barbour, Linda A Hawkins, Joy L Int J Womens Health Review Aplastic anemia is a hematologic condition occasionally presenting during pregnancy. This pathological process is associated with significant maternal and neonatal morbidity and mortality. Obstetric and anesthetic management is challenging, and treatment requires a coordinated effort by an interdisciplinary team, in order to provide safe care to these patients. In this review, we describe the current state of the literature as it applies to the complexity of aplastic anemia in pregnancy, focusing on pathophysiologic aspects of the disease in pregnancy, as well as relevant obstetric and anesthetic considerations necessary to treat this challenging problem. A multidisciplinary-team approach to the management of aplastic anemia in pregnancy is necessary to coordinate prenatal care, optimize maternofetal outcomes, and plan peripartum interventions. Conservative transfusion management is critical to prevent alloimmunization. Although a safe threshold-platelet count for neuraxial anesthesia has not been established, selection of anesthetic technique must be evaluated on a case-to-case basis. Dove Medical Press 2018-02-28 /pmc/articles/PMC5836687/ /pubmed/29535558 http://dx.doi.org/10.2147/IJWH.S149683 Text en © 2018 Riveros-Perez et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Riveros-Perez, Efrain Hermesch, Amy C Barbour, Linda A Hawkins, Joy L Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations |
title | Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations |
title_full | Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations |
title_fullStr | Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations |
title_full_unstemmed | Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations |
title_short | Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations |
title_sort | aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836687/ https://www.ncbi.nlm.nih.gov/pubmed/29535558 http://dx.doi.org/10.2147/IJWH.S149683 |
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