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Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations

Aplastic anemia is a hematologic condition occasionally presenting during pregnancy. This pathological process is associated with significant maternal and neonatal morbidity and mortality. Obstetric and anesthetic management is challenging, and treatment requires a coordinated effort by an interdisc...

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Autores principales: Riveros-Perez, Efrain, Hermesch, Amy C, Barbour, Linda A, Hawkins, Joy L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836687/
https://www.ncbi.nlm.nih.gov/pubmed/29535558
http://dx.doi.org/10.2147/IJWH.S149683
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author Riveros-Perez, Efrain
Hermesch, Amy C
Barbour, Linda A
Hawkins, Joy L
author_facet Riveros-Perez, Efrain
Hermesch, Amy C
Barbour, Linda A
Hawkins, Joy L
author_sort Riveros-Perez, Efrain
collection PubMed
description Aplastic anemia is a hematologic condition occasionally presenting during pregnancy. This pathological process is associated with significant maternal and neonatal morbidity and mortality. Obstetric and anesthetic management is challenging, and treatment requires a coordinated effort by an interdisciplinary team, in order to provide safe care to these patients. In this review, we describe the current state of the literature as it applies to the complexity of aplastic anemia in pregnancy, focusing on pathophysiologic aspects of the disease in pregnancy, as well as relevant obstetric and anesthetic considerations necessary to treat this challenging problem. A multidisciplinary-team approach to the management of aplastic anemia in pregnancy is necessary to coordinate prenatal care, optimize maternofetal outcomes, and plan peripartum interventions. Conservative transfusion management is critical to prevent alloimmunization. Although a safe threshold-platelet count for neuraxial anesthesia has not been established, selection of anesthetic technique must be evaluated on a case-to-case basis.
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spelling pubmed-58366872018-03-13 Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations Riveros-Perez, Efrain Hermesch, Amy C Barbour, Linda A Hawkins, Joy L Int J Womens Health Review Aplastic anemia is a hematologic condition occasionally presenting during pregnancy. This pathological process is associated with significant maternal and neonatal morbidity and mortality. Obstetric and anesthetic management is challenging, and treatment requires a coordinated effort by an interdisciplinary team, in order to provide safe care to these patients. In this review, we describe the current state of the literature as it applies to the complexity of aplastic anemia in pregnancy, focusing on pathophysiologic aspects of the disease in pregnancy, as well as relevant obstetric and anesthetic considerations necessary to treat this challenging problem. A multidisciplinary-team approach to the management of aplastic anemia in pregnancy is necessary to coordinate prenatal care, optimize maternofetal outcomes, and plan peripartum interventions. Conservative transfusion management is critical to prevent alloimmunization. Although a safe threshold-platelet count for neuraxial anesthesia has not been established, selection of anesthetic technique must be evaluated on a case-to-case basis. Dove Medical Press 2018-02-28 /pmc/articles/PMC5836687/ /pubmed/29535558 http://dx.doi.org/10.2147/IJWH.S149683 Text en © 2018 Riveros-Perez et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Riveros-Perez, Efrain
Hermesch, Amy C
Barbour, Linda A
Hawkins, Joy L
Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations
title Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations
title_full Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations
title_fullStr Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations
title_full_unstemmed Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations
title_short Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations
title_sort aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836687/
https://www.ncbi.nlm.nih.gov/pubmed/29535558
http://dx.doi.org/10.2147/IJWH.S149683
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