Cargando…
Effects of pH, conductivity, host cell protein, and DNA size distribution on DNA clearance in anion exchange chromatography media
Flowthrough anion exchange chromatography is commonly used as a polishing step in downstream processing of monoclonal antibodies and other therapeutic proteins to remove process‐related impurities and contaminants such as host cell DNA, host cell proteins, endotoxin, and viruses. DNA with a wide ran...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836906/ https://www.ncbi.nlm.nih.gov/pubmed/28884511 http://dx.doi.org/10.1002/btpr.2556 |