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Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

Oncogene-induced DNA replication stress contributes critically to the genomic instability present in cancer1–4. However, elucidating how oncogenes deregulate DNA replication has been impeded by the difficulty in mapping replication initiation sites on the human genome. In this study, using a sensiti...

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Detalles Bibliográficos
Autores principales:	Macheret, Morgane, Halazonetis, Thanos D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837010/ https://www.ncbi.nlm.nih.gov/pubmed/29466339 http://dx.doi.org/10.1038/nature25507

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