Réactivation d’une hépatite B occulte chez un patient drépanocytaire homozygote: cas clinique et revue de la litérature

Occult Hepatitis B corresponds to the presence of hepatitis B virus-deoxyribonucleic acid (HBV-DNA) in serum and/or in liver of a patient despite HBsAg negativity. Clinically, it is usually asymptomatic. Its reactivation is rare and commonly occurs in immunosuppressed individuals. We report the case...

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Detalles Bibliográficos
Autores principales: Diop, Moustapha, Cisse-Diallo, Viviane Marie Pierre, Ka, Daye, Lakhe, Ndèye Aissatou, Diallo-Mbaye, Khardiata, Massaly, Aminata, Dièye, Alassane, Fall, Ndèye Maguette, Badiane, Aboubacar Sadikh, Thioub, Daouda, Fortes-Déguénonvo, Louise, Lo, Gora, Diop, Cheikh Tacko, Ndour, Cheikh Tidiane, Soumaré, Masserigne, Seydi, Moussa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837157/
https://www.ncbi.nlm.nih.gov/pubmed/29515745
http://dx.doi.org/10.11604/pamj.2017.28.127.13640
Descripción
Sumario:Occult Hepatitis B corresponds to the presence of hepatitis B virus-deoxyribonucleic acid (HBV-DNA) in serum and/or in liver of a patient despite HBsAg negativity. Clinically, it is usually asymptomatic. Its reactivation is rare and commonly occurs in immunosuppressed individuals. We report the case of a 21-year old patient from Senegal, with homozygous sickle cell disease, presenting with cholestatic jaundice. Laboratory tests showed reactivation of occult Hepatitis B. This study emphasizes the need to systematically investigate the presence of occult Hepatitis B in patients with sickle cell disease suffering from acute liver disease.

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