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Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012–2016
Aside from enterovirus 71 (EV71) and coxsackie virus A16 (CV-A16), viruses that are known to cause hand-foot-and-mouth disease (HFMD), epidemiological profiles of other enteroviruses that induce HFMD are limited. We collected 9949 laboratory surveillance HFMD cases and 1230 serum samples from infant...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837173/ https://www.ncbi.nlm.nih.gov/pubmed/29362406 http://dx.doi.org/10.1038/s41426-017-0011-z |
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author | Wang, Jiayu Teng, Zheng Cui, Xiaoqing Li, Chongshan Pan, Hao Zheng, Yaxu Mao, Shenghua Yang, Yuying Wu, Limeng Guo, Xiaokui Zhang, Xi Zhu, Yongzhang |
author_facet | Wang, Jiayu Teng, Zheng Cui, Xiaoqing Li, Chongshan Pan, Hao Zheng, Yaxu Mao, Shenghua Yang, Yuying Wu, Limeng Guo, Xiaokui Zhang, Xi Zhu, Yongzhang |
author_sort | Wang, Jiayu |
collection | PubMed |
description | Aside from enterovirus 71 (EV71) and coxsackie virus A16 (CV-A16), viruses that are known to cause hand-foot-and-mouth disease (HFMD), epidemiological profiles of other enteroviruses that induce HFMD are limited. We collected 9949 laboratory surveillance HFMD cases and 1230 serum samples from infants and children in Shanghai from 2012–2016. Since 2013, CV-A6 has displaced EV71 and CV-A16 to become the predominant serotype. Interestingly, novel epidemiological patterns in EV71 and CV-A16 infections were observed, with one large peak in both 2012 and 2014, followed by two smaller peaks in the respective following years (2013 and 2015). Through sequencing, we found that C4a, B1b, D-Cluster-1 and B constituted the major subgenotypes of EV71, CV-A16, CV-A6 and CV-A10, respectively. Among healthy individuals, 50.49% and 54.23% had positive neutralising antibodies (NtAbs) against EV71 and CV-A16, respectively, indicating that EV71 and CV-A16 silent infections were common. These populations may be an important potential source of infection. The overall seropositive rate of EV71 NtAbs showed a fluctuating, markedly downward trend, indicating the potential risk of a future EV71 epidemic. High CV-A16 NtAb seroprevalence corroborated a documented CV-A16 ‘silent’ epidemic. Children aged 1–5 years had the lowest EV71 NtAb seropositive rate, whereas those aged 1–2 years exhibited the lowest CV-A16 NtAb seropositive rate. This is the first comprehensive investigation of the epidemiology and aetiology, as well as the seroprevalence, of HFMD in Shanghai between 2012 and 2016. This study provides the latest insights into developing a more efficient HMFD vaccination programme. |
format | Online Article Text |
id | pubmed-5837173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58371732018-03-08 Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012–2016 Wang, Jiayu Teng, Zheng Cui, Xiaoqing Li, Chongshan Pan, Hao Zheng, Yaxu Mao, Shenghua Yang, Yuying Wu, Limeng Guo, Xiaokui Zhang, Xi Zhu, Yongzhang Emerg Microbes Infect Article Aside from enterovirus 71 (EV71) and coxsackie virus A16 (CV-A16), viruses that are known to cause hand-foot-and-mouth disease (HFMD), epidemiological profiles of other enteroviruses that induce HFMD are limited. We collected 9949 laboratory surveillance HFMD cases and 1230 serum samples from infants and children in Shanghai from 2012–2016. Since 2013, CV-A6 has displaced EV71 and CV-A16 to become the predominant serotype. Interestingly, novel epidemiological patterns in EV71 and CV-A16 infections were observed, with one large peak in both 2012 and 2014, followed by two smaller peaks in the respective following years (2013 and 2015). Through sequencing, we found that C4a, B1b, D-Cluster-1 and B constituted the major subgenotypes of EV71, CV-A16, CV-A6 and CV-A10, respectively. Among healthy individuals, 50.49% and 54.23% had positive neutralising antibodies (NtAbs) against EV71 and CV-A16, respectively, indicating that EV71 and CV-A16 silent infections were common. These populations may be an important potential source of infection. The overall seropositive rate of EV71 NtAbs showed a fluctuating, markedly downward trend, indicating the potential risk of a future EV71 epidemic. High CV-A16 NtAb seroprevalence corroborated a documented CV-A16 ‘silent’ epidemic. Children aged 1–5 years had the lowest EV71 NtAb seropositive rate, whereas those aged 1–2 years exhibited the lowest CV-A16 NtAb seropositive rate. This is the first comprehensive investigation of the epidemiology and aetiology, as well as the seroprevalence, of HFMD in Shanghai between 2012 and 2016. This study provides the latest insights into developing a more efficient HMFD vaccination programme. Nature Publishing Group UK 2018-01-24 /pmc/articles/PMC5837173/ /pubmed/29362406 http://dx.doi.org/10.1038/s41426-017-0011-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wang, Jiayu Teng, Zheng Cui, Xiaoqing Li, Chongshan Pan, Hao Zheng, Yaxu Mao, Shenghua Yang, Yuying Wu, Limeng Guo, Xiaokui Zhang, Xi Zhu, Yongzhang Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012–2016 |
title | Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012–2016 |
title_full | Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012–2016 |
title_fullStr | Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012–2016 |
title_full_unstemmed | Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012–2016 |
title_short | Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012–2016 |
title_sort | epidemiological and serological surveillance of hand-foot-and-mouth disease in shanghai, china, 2012–2016 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837173/ https://www.ncbi.nlm.nih.gov/pubmed/29362406 http://dx.doi.org/10.1038/s41426-017-0011-z |
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