A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii

Acinetobacter baumannii ATCC 19606 can grow without lipooligosaccharide (LOS). Lack of LOS can result from disruption of the early lipid A biosynthetic pathway genes lpxA, lpxC or lpxD. Although LOS itself is not essential for growth of A. baumannii ATCC 19606, it was previously shown that depletion...

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Detalles Bibliográficos
Autores principales: Richie, Daryl L., Wang, Lisha, Chan, Helen, De Pascale, Gianfranco, Six, David A., Wei, Jun-Rong, Dean, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837183/
https://www.ncbi.nlm.nih.gov/pubmed/29505586
http://dx.doi.org/10.1371/journal.pone.0193851

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