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Editor’s Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance

Styrene is a mouse-specific lung carcinogen, and short-term mode of action studies have demonstrated that cytotoxicity and/or cell proliferation, and genomic changes are dependent on CYP2F2 metabolism. The current study examined histopathology, cell proliferation, and genomic changes in CD-1, C57BL/...

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Detalles Bibliográficos
Autores principales:	Cruzan, George, Bus, James S., Banton, Marcy I., Sarang, Satinder S., Waites, Robbie, Layko, Debra B., Raymond, James, Dodd, Darol, Andersen, Melvin E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Lack of Human Relevance for Styrene Tumorogenecity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837194/ https://www.ncbi.nlm.nih.gov/pubmed/28962520 http://dx.doi.org/10.1093/toxsci/kfx141

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