The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis

A 65-year-old man, with a history of hypertension and hyperlipidemia, presented with intractable lower back pain, shortness of breath, and decreasing urine output at the emergency room and was admitted after he was found to have elevated creatinine kinase levels of greater than 160,000 U/L. We disco...

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Autores principales: Khan, Salman, Khan, Imran, Novak, Matthew, Regmi, Asish, Difilippo, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Family/General Practice
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837234/
https://www.ncbi.nlm.nih.gov/pubmed/29531873
http://dx.doi.org/10.7759/cureus.2020
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author Khan, Salman
Khan, Imran
Novak, Matthew
Regmi, Asish
Difilippo, William
author_facet Khan, Salman
Khan, Imran
Novak, Matthew
Regmi, Asish
Difilippo, William
author_sort Khan, Salman
collection PubMed
description A 65-year-old man, with a history of hypertension and hyperlipidemia, presented with intractable lower back pain, shortness of breath, and decreasing urine output at the emergency room and was admitted after he was found to have elevated creatinine kinase levels of greater than 160,000 U/L. We discontinued all his home medications, which included atorvastatin and amlodipine. We trended his creatine phosphokinase (CPK) level daily and noticed it decreasing significantly off these meds. We hydrated him with normal saline and monitored his kidney functions. By the time he was ready for discharge, his CPK levels were back to normal. This case report summarizes the drug-drug interactions of atorvastatin and amlodipine.
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spelling pubmed-58372342018-03-12 The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis Khan, Salman Khan, Imran Novak, Matthew Regmi, Asish Difilippo, William Cureus Family/General Practice A 65-year-old man, with a history of hypertension and hyperlipidemia, presented with intractable lower back pain, shortness of breath, and decreasing urine output at the emergency room and was admitted after he was found to have elevated creatinine kinase levels of greater than 160,000 U/L. We discontinued all his home medications, which included atorvastatin and amlodipine. We trended his creatine phosphokinase (CPK) level daily and noticed it decreasing significantly off these meds. We hydrated him with normal saline and monitored his kidney functions. By the time he was ready for discharge, his CPK levels were back to normal. This case report summarizes the drug-drug interactions of atorvastatin and amlodipine. Cureus 2018-01-03 /pmc/articles/PMC5837234/ /pubmed/29531873 http://dx.doi.org/10.7759/cureus.2020 Text en Copyright © 2018, Khan et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Family/General Practice
Khan, Salman
Khan, Imran
Novak, Matthew
Regmi, Asish
Difilippo, William
The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis
title The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis
title_full The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis
title_fullStr The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis
title_full_unstemmed The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis
title_short The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis
title_sort concomitant use of atorvastatin and amlodipine leading to rhabdomyolysis
topic Family/General Practice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837234/
https://www.ncbi.nlm.nih.gov/pubmed/29531873
http://dx.doi.org/10.7759/cureus.2020
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