A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target

Despite the development of newer anti-seizure medications over the past 50 years, 30–40% of patients with epilepsy remain refractory to treatment. One explanation for this lack of progress is that the current screening process is largely biased towards transmembrane channels and receptors, and ignor...

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Detalles Bibliográficos
Autores principales: Ibhazehiebo, Kingsley, Gavrilovici, Cezar, de la Hoz, Cristiane L, Ma, Shun-Chieh, Rehak, Renata, Kaushik, Gaurav, Meza Santoscoy, Paola L, Scott, Lucas, Nath, Nandan, Kim, Do-Young, Rho, Jong M, Kurrasch, Deborah M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837409/
https://www.ncbi.nlm.nih.gov/pubmed/29373639
http://dx.doi.org/10.1093/brain/awx364

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