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Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts

Fidaxomicin (Fdx) is an antimicrobial RNA polymerase (RNAP) inhibitor highly effective against Mycobacterium tuberculosis RNAP in vitro, but clinical use of Fdx is limited to treating Clostridium difficile intestinal infections due to poor absorption. To identify the structural determinants of Fdx b...

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Detalles Bibliográficos
Autores principales:	Boyaci, Hande, Chen, James, Lilic, Mirjana, Palka, Margaret, Mooney, Rachel Anne, Landick, Robert, Darst, Seth A, Campbell, Elizabeth A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837556/ https://www.ncbi.nlm.nih.gov/pubmed/29480804 http://dx.doi.org/10.7554/eLife.34823

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