From the Cover: Evaluation of the Effects of Tanezumab, a Monoclonal Antibody Against Nerve Growth Factor, on the Sympathetic Nervous System in Adult Cynomolgus Monkeys (Macaca fascicularis): A Stereologic, Histomorphologic, and Cardiofunctional Assessment

Tanezumab, a humanized monoclonal antibody against nerve growth factor is in development for treatment of chronic pain. Three nonclinical studies assessed effects of clinically relevant and supratherapeutic doses of tanezumab on the sympathetic nervous system (SNS) of adult nonhuman primates. Study...

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Detalles Bibliográficos
Autores principales: Belanger, Patrice, Butler, Paul, Butt, Mark, Bhatt, Siddhartha, Foote, Stephen, Shelton, David, Evans, Mark, Arends, Rosalinda, Hurst, Susan, Okerberg, Carlin, Cummings, Thomas, Potter, David, Steidl-Nichols, Jill, Zorbas, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Nerve Growth Factor Antibody Tanezumab and Sympathetic Nervous System Function
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837719/
https://www.ncbi.nlm.nih.gov/pubmed/28525647
http://dx.doi.org/10.1093/toxsci/kfx089

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