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Endogenous CHRNA7-ligand SLURP1 as a potential tumor suppressor and anti-nicotinic factor in pancreatic cancer

Smoking is associated with increased risk and poorer prognosis of pancreatic ductal adenocarcinoma (PDAC). Nicotine acts through cholinergic nicotinic receptors, preferentially α7 (CHRNA7) that also binds the endogenous ligand SLURP1 (Secreted Ly-6/uPAR-Related Protein 1). The clinical significance...

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Detalles Bibliográficos
Autores principales:	Throm, Verena M., Männle, David, Giese, Thomas, Bauer, Andrea S., Gaida, Matthias M., Kopitz, Juergen, Bruckner, Thomas, Plaschke, Konstanze, Grekova, Svetlana P., Felix, Klaus, Hackert, Thilo, Giese, Nathalia A., Strobel, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837762/ https://www.ncbi.nlm.nih.gov/pubmed/29545933 http://dx.doi.org/10.18632/oncotarget.24312

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