Cargando…

Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening

Protein arginine methyltransferase 5 (PRMT5) is able to regulate gene transcription by catalyzing the symmetrical dimethylation of arginine residue of histone, which plays a key role in tumorigenesis. Many efforts have been taken in discovering small-molecular inhibitors against PRMT5, but very few...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Qianqian, Xu, Jiahui, Li, Ying, Huang, Jumin, Jiang, Zebo, Wang, Yuwei, Liu, Liang, Leung, Elaine Lai Han, Yao, Xiaojun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838003/ https://www.ncbi.nlm.nih.gov/pubmed/29545752 http://dx.doi.org/10.3389/fphar.2018.00173

Ejemplares similares

Discovery of Novel IDH1 Inhibitor Through Comparative Structure-Based Virtual Screening
por: Wang, Yuwei, et al.
Publicado: (2020)

Gossypol Inhibits Non-small Cell Lung Cancer Cells Proliferation by Targeting EGFR(L858R/T790M)
por: Wang, Yuwei, et al.
Publicado: (2018)

The Role and Mechanism of Lysine Methyltransferase and Arginine Methyltransferase in Kidney Diseases
por: Zhou, Xun, et al.
Publicado: (2022)

Krukovine Suppresses KRAS-Mutated Lung Cancer Cell Growth and Proliferation by Inhibiting the RAF-ERK Pathway and Inactivating AKT Pathway
por: Lai, Huanling, et al.
Publicado: (2018)

3D-QSAR, Molecular Docking, and MD Simulations of Anthraquinone Derivatives as PGAM1 Inhibitors
por: Wang, Yuwei, et al.
Publicado: (2021)

Protein arginine methyltransferases in renal development, injury, repair, and fibrosis
por: Yu, Jianjun, et al.
Publicado: (2023)

Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays
por: Ye, Fei, et al.
Publicado: (2016)

Discovery of Novel HPK1 Inhibitors Through Structure-Based Virtual Screening
por: Ge, Huizhen, et al.
Publicado: (2022)

Discovery of METTL3 Small Molecule Inhibitors by Virtual Screening of Natural Products
por: Du, Yue, et al.
Publicado: (2022)

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor
por: Feoli, Alessandra, et al.
Publicado: (2023)

Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells
por: Xie, Chun, et al.
Publicado: (2017)

Identification of PARP12 Inhibitors By Virtual Screening and Molecular Dynamics Simulations
por: Almeleebia, Tahani M., et al.
Publicado: (2022)

Identification of super-enhancer-driven peptidyl arginine deiminases as potential biomarkers and therapeutic targets for osimertinib-resistant non-small cell lung cancer
por: Li, Hang, et al.
Publicado: (2022)

Recent progress in DNA methyltransferase inhibitors as anticancer agents
por: Zhang, Zhixiong, et al.
Publicado: (2022)

Virtual screening and activity evaluation of multitargeting inhibitors for idiopathic pulmonary fibrosis
por: Wang, Rui, et al.
Publicado: (2022)

Selective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations
por: Wang, Qianqian, et al.
Publicado: (2017)

Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity
por: Kong, Gui-Mei, et al.
Publicado: (2017)

Recent advances of IDH1 mutant inhibitor in cancer therapy
por: Tian, Wangqi, et al.
Publicado: (2022)

Identification of highly effective inhibitors against SARS-CoV-2 main protease: From virtual screening to in vitro study
por: Wang, Hu, et al.
Publicado: (2022)

Identification of potential extracellular signal-regulated protein kinase 2 inhibitors based on multiple virtual screening strategies
por: Yang, Ruoqi, et al.
Publicado: (2022)

Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening
por: Zhang, Guoqing, et al.
Publicado: (2018)

Protein arginine methyltransferase 6 is a novel substrate of protein arginine methyltransferase 1
por: Cao, Meng-Tong, et al.
Publicado: (2023)

A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes
por: Iyamu, Iredia D., et al.
Publicado: (2021)

Crystal Structure of Arginine Methyltransferase 6 from Trypanosoma brucei
por: Wang, Chongyuan, et al.
Publicado: (2014)

Inhibitors of DNA Methyltransferases From Natural Sources: A Computational Perspective
por: Saldívar-González, Fernanda I., et al.
Publicado: (2018)

Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach
por: Iannelli, Giulia, et al.
Publicado: (2022)

Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through in silico and in vitro screening
por: Shi, Danfeng, et al.
Publicado: (2022)

The Development of Tetrazole Derivatives as Protein Arginine Methyltransferase I (PRMT I) Inhibitors
por: Sun, Yutong, et al.
Publicado: (2019)

Discovery of potent and noncovalent KRAS(G12D) inhibitors: Structure-based virtual screening and biological evaluation
por: Wang, Yuting, et al.
Publicado: (2022)

Editorial: Pharmacology of L-Arginine and L-Arginine-Rich Food
por: Poeggeler, Burkhard, et al.
Publicado: (2021)

Identification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1
por: Li, Xiaoguang, et al.
Publicado: (2017)

Arginine methyltransferase inhibitor-1 inhibits sarcoma viability in vitro and in vivo
por: Zhang, Baolai, et al.
Publicado: (2018)

Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6
por: Gong, Shuai, et al.
Publicado: (2021)

Discovery of novel IDH1-R132C inhibitors through structure-based virtual screening
por: Hu, Chujiao, et al.
Publicado: (2022)

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers
por: Prabhu, Lakshmi, et al.
Publicado: (2017)

Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
por: Dong, Rui, et al.
Publicado: (2021)

Identification of novel and potent dual-targeting HDAC1/SPOP inhibitors using structure-based virtual screening, molecular dynamics simulation and evaluation of in vitro and in vivo antitumor activity
por: Yang, Yingxue, et al.
Publicado: (2023)

Discovery of Potent Disheveled/Dvl Inhibitors Using Virtual Screening Optimized With NMR-Based Docking Performance Index
por: Hori, Kiminori, et al.
Publicado: (2018)

Novel Histone Deacetylase Inhibitors and HIV-1 Latency-Reversing Agents Identified by Large-Scale Virtual Screening
por: Divsalar, Donya Naz, et al.
Publicado: (2020)

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors
por: Lin, Hong, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_pjj2mpkfahhi19inhhgfp7ctov