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Type 2 diabetes mellitus and non-alcoholic fatty liver disease: a systematic review and meta-analysis
AIM: The aim of this study was the evaluation of the prevalence of NAFLD in patients with type 2 diabetes mellitus. BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease with high prevalence in patients with type 2 diabetes mellitus (T2DM). Many studies have reported the preva...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838173/ https://www.ncbi.nlm.nih.gov/pubmed/29511464 |
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author | Amiri Dash Atan, Nasrin Koushki, Mehdi Motedayen, Morteza Dousti, Majid Sayehmiri, Fatemeh Vafaee, Reza Norouzinia, Mohsen Gholami, Reza |
author_facet | Amiri Dash Atan, Nasrin Koushki, Mehdi Motedayen, Morteza Dousti, Majid Sayehmiri, Fatemeh Vafaee, Reza Norouzinia, Mohsen Gholami, Reza |
author_sort | Amiri Dash Atan, Nasrin |
collection | PubMed |
description | AIM: The aim of this study was the evaluation of the prevalence of NAFLD in patients with type 2 diabetes mellitus. BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease with high prevalence in patients with type 2 diabetes mellitus (T2DM). Many studies have reported the prevalence of NAFLD in type 2 diabetes mellitus patients. However, these results are inconsistent. METHODS: A Literature search was conducted in PubMed, Scopus, web of science and Science Direct from 2005 to August 2017. The necessary information was extracted. Heterogeneity was evaluated using I(2) statistic. Meta-regression analyses were performed to the estimation of the relationship between the year of study and sample size with the prevalence of NAFLD. Publication bias was assessed by both Begg rank correlation and Egger tests. Subgroup analysis was performed for identification of sources heterogeneity. RESULTS: Seventeen studies involving 10897 type 2 diabetes mellitus patients with NAFLD were included in this meta-analysis. The overall prevalence of NAFLD in type 2 diabetes mellitus patients by random effects models was 54% (95% CI, 45%- 64%). There is a significant heterogeneity across studies with (I(2)= 99%, p> 0.01). The funnel plot as graphically and Begg and Egger as statistically showed no publication bias among studies. Subgroup analysis indicated that the prevalence of NAFLD in type 2 diabetes mellitus patients differed in predictive factors such as lipid profile, BMI, HbA1c, AST, and ALT. This finding in spite of heterogeneity of documents is corresponding to the positive correlation between NAFLD and type 2 diabetes mellitus. CONCLUSION: The findings indicated that the overall prevalence of NAFLD among type 2 diabetes mellitus patients is significantly higher. It can be concluded that type 2 diabetes mellitus patients should be managed to prevent NAFLD. |
format | Online Article Text |
id | pubmed-5838173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-58381732018-03-06 Type 2 diabetes mellitus and non-alcoholic fatty liver disease: a systematic review and meta-analysis Amiri Dash Atan, Nasrin Koushki, Mehdi Motedayen, Morteza Dousti, Majid Sayehmiri, Fatemeh Vafaee, Reza Norouzinia, Mohsen Gholami, Reza Gastroenterol Hepatol Bed Bench Review Article AIM: The aim of this study was the evaluation of the prevalence of NAFLD in patients with type 2 diabetes mellitus. BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease with high prevalence in patients with type 2 diabetes mellitus (T2DM). Many studies have reported the prevalence of NAFLD in type 2 diabetes mellitus patients. However, these results are inconsistent. METHODS: A Literature search was conducted in PubMed, Scopus, web of science and Science Direct from 2005 to August 2017. The necessary information was extracted. Heterogeneity was evaluated using I(2) statistic. Meta-regression analyses were performed to the estimation of the relationship between the year of study and sample size with the prevalence of NAFLD. Publication bias was assessed by both Begg rank correlation and Egger tests. Subgroup analysis was performed for identification of sources heterogeneity. RESULTS: Seventeen studies involving 10897 type 2 diabetes mellitus patients with NAFLD were included in this meta-analysis. The overall prevalence of NAFLD in type 2 diabetes mellitus patients by random effects models was 54% (95% CI, 45%- 64%). There is a significant heterogeneity across studies with (I(2)= 99%, p> 0.01). The funnel plot as graphically and Begg and Egger as statistically showed no publication bias among studies. Subgroup analysis indicated that the prevalence of NAFLD in type 2 diabetes mellitus patients differed in predictive factors such as lipid profile, BMI, HbA1c, AST, and ALT. This finding in spite of heterogeneity of documents is corresponding to the positive correlation between NAFLD and type 2 diabetes mellitus. CONCLUSION: The findings indicated that the overall prevalence of NAFLD among type 2 diabetes mellitus patients is significantly higher. It can be concluded that type 2 diabetes mellitus patients should be managed to prevent NAFLD. Shaheed Beheshti University of Medical Sciences 2017 /pmc/articles/PMC5838173/ /pubmed/29511464 Text en ©2017 RIGLD, Research Institute for Gastroenterology and Liver Diseases This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Amiri Dash Atan, Nasrin Koushki, Mehdi Motedayen, Morteza Dousti, Majid Sayehmiri, Fatemeh Vafaee, Reza Norouzinia, Mohsen Gholami, Reza Type 2 diabetes mellitus and non-alcoholic fatty liver disease: a systematic review and meta-analysis |
title | Type 2 diabetes mellitus and non-alcoholic fatty liver disease: a systematic review and meta-analysis |
title_full | Type 2 diabetes mellitus and non-alcoholic fatty liver disease: a systematic review and meta-analysis |
title_fullStr | Type 2 diabetes mellitus and non-alcoholic fatty liver disease: a systematic review and meta-analysis |
title_full_unstemmed | Type 2 diabetes mellitus and non-alcoholic fatty liver disease: a systematic review and meta-analysis |
title_short | Type 2 diabetes mellitus and non-alcoholic fatty liver disease: a systematic review and meta-analysis |
title_sort | type 2 diabetes mellitus and non-alcoholic fatty liver disease: a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838173/ https://www.ncbi.nlm.nih.gov/pubmed/29511464 |
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