Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor

Thyroid stimulating hormone receptor (TSHR), a G-protein-coupled receptor, is important for thyroid development and growth. In several cases, frameshift and/or nonsense mutations in TSHR were found in the patients with congenital hypothyroidism (CH), however they have not been functionally studied i...

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Detalles Bibliográficos
Autores principales: Yang, Jianqiang, Yi, Ning, Zhang, Junhui, He, Wen, He, Di, Wu, Wanwan, Xu, Shuyang, Li, Feng, Fan, Guoping, Zhu, Xianmin, Xue, Zhigang, Zhou, Wensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838214/
https://www.ncbi.nlm.nih.gov/pubmed/29507327
http://dx.doi.org/10.1038/s41598-018-22405-7

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