MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

Autophagy is the major cellular pathway by which macromolecules are degraded, and amino acid depletion powerfully activates autophagy. MAP4K3, or germinal-center kinase-like kinase, is required for robust cell growth in response to amino acids, but the basis for MAP4K3 regulation of cellular metabol...

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Detalles Bibliográficos
Autores principales: Hsu, Cynthia L., Lee, Elian X., Gordon, Kara L., Paz, Edwin A., Shen, Wen-Chuan, Ohnishi, Kohta, Meisenhelder, Jill, Hunter, Tony, La Spada, Albert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838220/
https://www.ncbi.nlm.nih.gov/pubmed/29507340
http://dx.doi.org/10.1038/s41467-018-03340-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838220/
https://www.ncbi.nlm.nih.gov/pubmed/29507340
http://dx.doi.org/10.1038/s41467-018-03340-7

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