Direct Factor X sequestration by systemic amyloid light‐chain amyloidosis

We present a lymphoplasmacytic lymphoma patient with Factor X (FX) deficiency. Despite the absence of FX inhibitor, the administration of fresh frozen plasma and anti‐inhibitor coagulant complex did not increase the FX level. The autopsy showed that massive amyloid depositions to multiple organs and...

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Detalles Bibliográficos
Autores principales: Tashiro, Haruko, Shirasaki, Ryosuke, Watanabe, Masato, Kawasugi, Kazuo, Takahashi, Yoshihisa, Shirafuji, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838284/
https://www.ncbi.nlm.nih.gov/pubmed/29531730
http://dx.doi.org/10.1002/ccr3.1398
Descripción
Sumario:We present a lymphoplasmacytic lymphoma patient with Factor X (FX) deficiency. Despite the absence of FX inhibitor, the administration of fresh frozen plasma and anti‐inhibitor coagulant complex did not increase the FX level. The autopsy showed that massive amyloid depositions to multiple organs and FX existed in union with amyloidosis.

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