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Serum Nesfatin-1 Levels in Girls with Idiopathic Central Precocious Puberty
OBJECTIVE: Nesfatin-1, an anorexigenic neuropeptide, is expressed mainly in the central nervous system and in some peripheral tissues. The role of nesfatin-1 in energy balance has been investigated. Despite the suggestion of a role for nesfatin-1 in reproductive function, data are limited on the rol...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838378/ https://www.ncbi.nlm.nih.gov/pubmed/28739555 http://dx.doi.org/10.4274/jcrpe.4677 |
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author | Altıncık, Ayça Sayın, Oya |
author_facet | Altıncık, Ayça Sayın, Oya |
author_sort | Altıncık, Ayça |
collection | PubMed |
description | OBJECTIVE: Nesfatin-1, an anorexigenic neuropeptide, is expressed mainly in the central nervous system and in some peripheral tissues. The role of nesfatin-1 in energy balance has been investigated. Despite the suggestion of a role for nesfatin-1 in reproductive function, data are limited on the role of nesfatin-1 in human puberty. METHODS: The aim of this study was to investigate the following: i) the role of nesfatin-1 in puberty, and ii) relationship between nesfatin-1 and anthropometric measurements and gonadotropin levels in girls with idiopathic central precocious puberty (CPP). Twenty-four girls with CPP (7.68±1.02 years) and 20 female, prepubertal, healthy controls (7.48±0.88 years) were enrolled in the study. All patients with CPP were treated by the intramuscular administration of leuprolide acetate at a daily dose of 3.75 mg for 28 days. Nesfatin-1 was measured before and during treatment. RESULTS: There was no difference in serum nesfatin-1 levels in girls with CPP and healthy controls [5.67 (2.5-20.6) mmol/L and 5.75 (2.51-9.64) mmol/L], respectively. There was a negative correlation between nesfatin-1 levels and body weight and body mass index-standard deviation score (p=0.01, r=-0.83; p=0.025, r=-0.81, respectively). No correlation was found between nesfatin-1 and gonadotropin, estradiol levels, uterine length or endometrial thickness. CONCLUSION: The results of this study suggest that there are no differences between girls with CPP and healthy, prepubertal girls regarding nesfatin-1 levels. |
format | Online Article Text |
id | pubmed-5838378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-58383782018-03-08 Serum Nesfatin-1 Levels in Girls with Idiopathic Central Precocious Puberty Altıncık, Ayça Sayın, Oya J Clin Res Pediatr Endocrinol Original Article OBJECTIVE: Nesfatin-1, an anorexigenic neuropeptide, is expressed mainly in the central nervous system and in some peripheral tissues. The role of nesfatin-1 in energy balance has been investigated. Despite the suggestion of a role for nesfatin-1 in reproductive function, data are limited on the role of nesfatin-1 in human puberty. METHODS: The aim of this study was to investigate the following: i) the role of nesfatin-1 in puberty, and ii) relationship between nesfatin-1 and anthropometric measurements and gonadotropin levels in girls with idiopathic central precocious puberty (CPP). Twenty-four girls with CPP (7.68±1.02 years) and 20 female, prepubertal, healthy controls (7.48±0.88 years) were enrolled in the study. All patients with CPP were treated by the intramuscular administration of leuprolide acetate at a daily dose of 3.75 mg for 28 days. Nesfatin-1 was measured before and during treatment. RESULTS: There was no difference in serum nesfatin-1 levels in girls with CPP and healthy controls [5.67 (2.5-20.6) mmol/L and 5.75 (2.51-9.64) mmol/L], respectively. There was a negative correlation between nesfatin-1 levels and body weight and body mass index-standard deviation score (p=0.01, r=-0.83; p=0.025, r=-0.81, respectively). No correlation was found between nesfatin-1 and gonadotropin, estradiol levels, uterine length or endometrial thickness. CONCLUSION: The results of this study suggest that there are no differences between girls with CPP and healthy, prepubertal girls regarding nesfatin-1 levels. Galenos Publishing 2018-03 2018-02-26 /pmc/articles/PMC5838378/ /pubmed/28739555 http://dx.doi.org/10.4274/jcrpe.4677 Text en © Copyright 2018, Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Altıncık, Ayça Sayın, Oya Serum Nesfatin-1 Levels in Girls with Idiopathic Central Precocious Puberty |
title | Serum Nesfatin-1 Levels in Girls with Idiopathic Central Precocious Puberty |
title_full | Serum Nesfatin-1 Levels in Girls with Idiopathic Central Precocious Puberty |
title_fullStr | Serum Nesfatin-1 Levels in Girls with Idiopathic Central Precocious Puberty |
title_full_unstemmed | Serum Nesfatin-1 Levels in Girls with Idiopathic Central Precocious Puberty |
title_short | Serum Nesfatin-1 Levels in Girls with Idiopathic Central Precocious Puberty |
title_sort | serum nesfatin-1 levels in girls with idiopathic central precocious puberty |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838378/ https://www.ncbi.nlm.nih.gov/pubmed/28739555 http://dx.doi.org/10.4274/jcrpe.4677 |
work_keys_str_mv | AT altıncıkayca serumnesfatin1levelsingirlswithidiopathiccentralprecociouspuberty AT sayınoya serumnesfatin1levelsingirlswithidiopathiccentralprecociouspuberty |