Cover Feature: Organometallic Nucleosides: Synthesis and Biological Evaluation of Substituted Dicobalt Hexacarbonyl 2′‐Deoxy‐5‐oxopropynyluridines (ChemistryOpen 3/2018)

The Cover Feature focuses on the crystal structure of dicobalt‐hexacarbonyl‐modified 5‐alkynyl‐2′‐deoxyuridine, which was investigated for in vitro antiproliferative activity against human cancer cells. The formation of reactive oxygen species in K562 cells implicates the involvement of oxidative st...

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Detalles Bibliográficos
Autores principales: Kaczmarek, Renata, Korczyński, Dariusz, Królewska‐Golińska, Karolina, Wheeler, Kraig A., Chavez, Ferman A., Mikus, Agnieszka, Dembinski, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838386/
http://dx.doi.org/10.1002/open.201800018
Descripción
Sumario:The Cover Feature focuses on the crystal structure of dicobalt‐hexacarbonyl‐modified 5‐alkynyl‐2′‐deoxyuridine, which was investigated for in vitro antiproliferative activity against human cancer cells. The formation of reactive oxygen species in K562 cells implicates the involvement of oxidative stress in the mode of action. Cover art by Samantha McCarthy. More information can be found in the Full Paper by R. Kaczmarek, R. Dembinski, et al. on page 237 in Issue 3, 2018 (DOI: 10.1002/open.201700168).[Image: see text]

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