A humanized monoclonal antibody that inhibits platelet‐surface ERp72 reveals a role for ERp72 in thrombosis

ESSENTIALS: ERp72 is a thiol isomerase enzyme. ERp72 levels increase at the platelet surface during platelet activation. We generated a humanized monoclonal antibody which blocks ERp72 enzyme activity (anti‐ERp72). Anti‐ERp72 inhibits platelet functional responses and thrombosis. SUMMARY: BACKGROUND...

Descripción completa

Detalles Bibliográficos
Autores principales: Holbrook, L.‐M., Sandhar, G. K., Sasikumar, P., Schenk, M. P., Stainer, A. R., Sahli, K. A., Flora, G. D., Bicknell, A. B., Gibbins, J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
PLATELETS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838528/
https://www.ncbi.nlm.nih.gov/pubmed/29052936
http://dx.doi.org/10.1111/jth.13878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838528/
https://www.ncbi.nlm.nih.gov/pubmed/29052936
http://dx.doi.org/10.1111/jth.13878

Ejemplares similares