Cargando…
Acne in late adolescence and risk of prostate cancer
Accumulating evidence suggest that Propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. The aim of this population‐based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an inc...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838533/ https://www.ncbi.nlm.nih.gov/pubmed/29205339 http://dx.doi.org/10.1002/ijc.31192 |
_version_ | 1783304279040196608 |
---|---|
author | Ugge, Henrik Udumyan, Ruzan Carlsson, Jessica Andrén, Ove Montgomery, Scott Davidsson, Sabina Fall, Katja |
author_facet | Ugge, Henrik Udumyan, Ruzan Carlsson, Jessica Andrén, Ove Montgomery, Scott Davidsson, Sabina Fall, Katja |
author_sort | Ugge, Henrik |
collection | PubMed |
description | Accumulating evidence suggest that Propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. The aim of this population‐based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. We identified a large cohort of young men born in Sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the age of 18 (n = 243,187). Test information along with health data including medical diagnoses at time of conscription was available through the Swedish Military Conscription Register and the National Patient Register. The cohort was followed through linkages to the Swedish Cancer Register to identify the occurrence of prostate cancer until December 31, 2009. We used Cox regression to calculate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between acne in adolescence and prostate cancer risk. A total of 1,633 men were diagnosed with prostate cancer during a median follow‐up of 36.7 years. A diagnosis of acne was associated with a statistically significant increased risk for prostate cancer (adjusted HR: 1.43 95%; CI: 1.06–1.92), particularly for advanced stage disease (HR: 2.37 95%; CI 1.19–4.73). A diagnosis of acne classified as severe conferred a sixfold increased risk of prostate cancer (HR: 5.70 95% CI 1.42–22.85). Data from this large prospective population‐based cohort add new evidence supporting a role of P. acnes infection in prostate cancer. |
format | Online Article Text |
id | pubmed-5838533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58385332018-03-12 Acne in late adolescence and risk of prostate cancer Ugge, Henrik Udumyan, Ruzan Carlsson, Jessica Andrén, Ove Montgomery, Scott Davidsson, Sabina Fall, Katja Int J Cancer Cancer Epidemiology Accumulating evidence suggest that Propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. The aim of this population‐based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. We identified a large cohort of young men born in Sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the age of 18 (n = 243,187). Test information along with health data including medical diagnoses at time of conscription was available through the Swedish Military Conscription Register and the National Patient Register. The cohort was followed through linkages to the Swedish Cancer Register to identify the occurrence of prostate cancer until December 31, 2009. We used Cox regression to calculate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between acne in adolescence and prostate cancer risk. A total of 1,633 men were diagnosed with prostate cancer during a median follow‐up of 36.7 years. A diagnosis of acne was associated with a statistically significant increased risk for prostate cancer (adjusted HR: 1.43 95%; CI: 1.06–1.92), particularly for advanced stage disease (HR: 2.37 95%; CI 1.19–4.73). A diagnosis of acne classified as severe conferred a sixfold increased risk of prostate cancer (HR: 5.70 95% CI 1.42–22.85). Data from this large prospective population‐based cohort add new evidence supporting a role of P. acnes infection in prostate cancer. John Wiley and Sons Inc. 2017-12-14 2018-04-15 /pmc/articles/PMC5838533/ /pubmed/29205339 http://dx.doi.org/10.1002/ijc.31192 Text en © 2017 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of Union for International Cancer Control This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Epidemiology Ugge, Henrik Udumyan, Ruzan Carlsson, Jessica Andrén, Ove Montgomery, Scott Davidsson, Sabina Fall, Katja Acne in late adolescence and risk of prostate cancer |
title | Acne in late adolescence and risk of prostate cancer |
title_full | Acne in late adolescence and risk of prostate cancer |
title_fullStr | Acne in late adolescence and risk of prostate cancer |
title_full_unstemmed | Acne in late adolescence and risk of prostate cancer |
title_short | Acne in late adolescence and risk of prostate cancer |
title_sort | acne in late adolescence and risk of prostate cancer |
topic | Cancer Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838533/ https://www.ncbi.nlm.nih.gov/pubmed/29205339 http://dx.doi.org/10.1002/ijc.31192 |
work_keys_str_mv | AT uggehenrik acneinlateadolescenceandriskofprostatecancer AT udumyanruzan acneinlateadolescenceandriskofprostatecancer AT carlssonjessica acneinlateadolescenceandriskofprostatecancer AT andrenove acneinlateadolescenceandriskofprostatecancer AT montgomeryscott acneinlateadolescenceandriskofprostatecancer AT davidssonsabina acneinlateadolescenceandriskofprostatecancer AT fallkatja acneinlateadolescenceandriskofprostatecancer |