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Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis

BACKGROUND: An increasing number of studies have investigated associations between collagen IX alpha 2 chain (COL9A2) and collagen IX alpha 3 chain (COL9A3) gene polymorphisms and the risk of lumbar disc degeneration (LDD). However, these studies have yielded contradictory results. The purpose of th...

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Autores principales: Wu, Huihong, Wang, Siting, Chen, Weiyou, Zhan, Xinli, Xiao, Zengming, Jiang, Hua, Wei, Qingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838857/
https://www.ncbi.nlm.nih.gov/pubmed/29506578
http://dx.doi.org/10.1186/s13018-018-0750-0
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author Wu, Huihong
Wang, Siting
Chen, Weiyou
Zhan, Xinli
Xiao, Zengming
Jiang, Hua
Wei, Qingjun
author_facet Wu, Huihong
Wang, Siting
Chen, Weiyou
Zhan, Xinli
Xiao, Zengming
Jiang, Hua
Wei, Qingjun
author_sort Wu, Huihong
collection PubMed
description BACKGROUND: An increasing number of studies have investigated associations between collagen IX alpha 2 chain (COL9A2) and collagen IX alpha 3 chain (COL9A3) gene polymorphisms and the risk of lumbar disc degeneration (LDD). However, these studies have yielded contradictory results. The purpose of this meta-analysis is to investigate the association between the collagen IX gene polymorphisms (rs12077871, rs12722877, rs7533552 in COL9A2; rs61734651 in COL9A3) and LDD. METHODS: All relevant articles were collected from PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI). The last electronic search was performed on September 1, 2017. The allele/genotype frequencies were extracted from each study. The odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of associations under the five comparison genetic models. Statistical analysis was performed by Review Manager (RevMan) 5.31 software. RESULTS: The meta-analysis of 10 case-control studies, including 2102 LDD cases and 2507 controls, indicated that COL9A2 gene (rs12077871, rs12722877, rs7533552) and COL9A3 gene (rs61734651) polymorphisms were not associated with LDD (rs12077871: T vs. C, OR = 1.85, 95% CI = 0.87–3.91, P = 0.11; rs12722877: G vs. C, OR = 0.83, 95% CI = 0.69–1.01, P = 0.06; rs7533552: G vs. A, OR = 1.11, 95% CI = 0.98–1.25, P = 0.09; rs61734651: T vs. C, OR = 1.57, 95% CI = 0.51–4.84, P = 0.43). The Egger text and the Begg funnel plot did not show any evidence of publication bias. CONCLUSION: rs12077871, rs12722877, and rs7533552 variants in COL9A2 and rs61734651 variant in COL9A3 were not significantly associated with a predisposition to LDD. Large-scale and well-designed studies are needed to confirm this conclusion.
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spelling pubmed-58388572018-03-09 Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis Wu, Huihong Wang, Siting Chen, Weiyou Zhan, Xinli Xiao, Zengming Jiang, Hua Wei, Qingjun J Orthop Surg Res Research Article BACKGROUND: An increasing number of studies have investigated associations between collagen IX alpha 2 chain (COL9A2) and collagen IX alpha 3 chain (COL9A3) gene polymorphisms and the risk of lumbar disc degeneration (LDD). However, these studies have yielded contradictory results. The purpose of this meta-analysis is to investigate the association between the collagen IX gene polymorphisms (rs12077871, rs12722877, rs7533552 in COL9A2; rs61734651 in COL9A3) and LDD. METHODS: All relevant articles were collected from PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI). The last electronic search was performed on September 1, 2017. The allele/genotype frequencies were extracted from each study. The odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of associations under the five comparison genetic models. Statistical analysis was performed by Review Manager (RevMan) 5.31 software. RESULTS: The meta-analysis of 10 case-control studies, including 2102 LDD cases and 2507 controls, indicated that COL9A2 gene (rs12077871, rs12722877, rs7533552) and COL9A3 gene (rs61734651) polymorphisms were not associated with LDD (rs12077871: T vs. C, OR = 1.85, 95% CI = 0.87–3.91, P = 0.11; rs12722877: G vs. C, OR = 0.83, 95% CI = 0.69–1.01, P = 0.06; rs7533552: G vs. A, OR = 1.11, 95% CI = 0.98–1.25, P = 0.09; rs61734651: T vs. C, OR = 1.57, 95% CI = 0.51–4.84, P = 0.43). The Egger text and the Begg funnel plot did not show any evidence of publication bias. CONCLUSION: rs12077871, rs12722877, and rs7533552 variants in COL9A2 and rs61734651 variant in COL9A3 were not significantly associated with a predisposition to LDD. Large-scale and well-designed studies are needed to confirm this conclusion. BioMed Central 2018-03-05 /pmc/articles/PMC5838857/ /pubmed/29506578 http://dx.doi.org/10.1186/s13018-018-0750-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wu, Huihong
Wang, Siting
Chen, Weiyou
Zhan, Xinli
Xiao, Zengming
Jiang, Hua
Wei, Qingjun
Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis
title Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis
title_full Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis
title_fullStr Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis
title_full_unstemmed Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis
title_short Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis
title_sort collagen ix gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838857/
https://www.ncbi.nlm.nih.gov/pubmed/29506578
http://dx.doi.org/10.1186/s13018-018-0750-0
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