Cargando…

Maternal and Perinatal Outcome in Gestational Diabetes Mellitus in a Tertiary Care Hospital in Delhi

BACKGROUND: Gestational diabetes mellitus (GDM) is defined as a carbohydrate intolerance first diagnosed in pregnancy and may be associated with adverse maternal and perinatal outcome. AIM: The aim of the study was to determine the maternal and perinatal outcome in GDM during pregnancy. MATERIALS AN...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumari, Rajesh, Dalal, Venus, Kachhawa, Garima, Sahoo, Ipshita, Khadgawat, Rajesh, Mahey, Reeta, Kulshrestha, Vidushi, Vanamail, Perumal, Sharma, J. B., Bhatla, Neerja, Kriplani, Alka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838890/
https://www.ncbi.nlm.nih.gov/pubmed/29535949
http://dx.doi.org/10.4103/ijem.IJEM_582_17
_version_ 1783304324572512256
author Kumari, Rajesh
Dalal, Venus
Kachhawa, Garima
Sahoo, Ipshita
Khadgawat, Rajesh
Mahey, Reeta
Kulshrestha, Vidushi
Vanamail, Perumal
Sharma, J. B.
Bhatla, Neerja
Kriplani, Alka
author_facet Kumari, Rajesh
Dalal, Venus
Kachhawa, Garima
Sahoo, Ipshita
Khadgawat, Rajesh
Mahey, Reeta
Kulshrestha, Vidushi
Vanamail, Perumal
Sharma, J. B.
Bhatla, Neerja
Kriplani, Alka
author_sort Kumari, Rajesh
collection PubMed
description BACKGROUND: Gestational diabetes mellitus (GDM) is defined as a carbohydrate intolerance first diagnosed in pregnancy and may be associated with adverse maternal and perinatal outcome. AIM: The aim of the study was to determine the maternal and perinatal outcome in GDM during pregnancy. MATERIALS AND METHODS: It is a retrospective analysis of women diagnosed with GDM who got antenatal care and delivered in our hospital in previous 5 years. Another 191 women with normal pregnancy without GDM and other medical conditions were taken as control. The baseline characteristics (age, body mass index, religion, and socioeconomic status) were noted in all cases. Diagnosis of GDM was made using oral glucose tolerance test with 75 g glucose. GDM patients were started on diet following which insulin or oral hypoglycemic agents were given if required. Maternal and perinatal outcome was noted in all women. RESULTS: The prevalence of GDM was 5.72% (170/2970). Most patients (79.41%) could be controlled on diet alone. However, 21 (12.35%) needed insulin and 14 (8.23%) needed oral hypoglycemic agents. Middle socioeconomic status was more common in GDM than control and pregnancy-induced hypertension was more common in GDM (13.5%) than in control (6.3%) (P = 0.019). Mode of delivery was not different in two groups. Instrumental deliveries and postpartum hemorrhage were also similar. However, mean birth weight was significantly higher in GDM (2848 ± 539 g) than in control (2707 ± 641 g) (P = 0.004). Incidence of large-for-date babies was also higher (28.2%) in GDM than control (19.4%) (P = 0.005). In neonatal complication, hypoglycemia was significantly higher in GDM (20.6%) than in control (5.2%) (P = 0.001). However, the incidence of hyperbilirubinemia and congenital malformations was not significantly different in two groups. CONCLUSION: The prevalence of GDM was 5.72% in this study. Adequate treatment of GDM on diet, oral hypoglycemic agents, or insulin to achieve euglycemia can achieve near-normal maternal and neonatal outcome.
format Online
Article
Text
id pubmed-5838890
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-58388902018-03-13 Maternal and Perinatal Outcome in Gestational Diabetes Mellitus in a Tertiary Care Hospital in Delhi Kumari, Rajesh Dalal, Venus Kachhawa, Garima Sahoo, Ipshita Khadgawat, Rajesh Mahey, Reeta Kulshrestha, Vidushi Vanamail, Perumal Sharma, J. B. Bhatla, Neerja Kriplani, Alka Indian J Endocrinol Metab Original Article BACKGROUND: Gestational diabetes mellitus (GDM) is defined as a carbohydrate intolerance first diagnosed in pregnancy and may be associated with adverse maternal and perinatal outcome. AIM: The aim of the study was to determine the maternal and perinatal outcome in GDM during pregnancy. MATERIALS AND METHODS: It is a retrospective analysis of women diagnosed with GDM who got antenatal care and delivered in our hospital in previous 5 years. Another 191 women with normal pregnancy without GDM and other medical conditions were taken as control. The baseline characteristics (age, body mass index, religion, and socioeconomic status) were noted in all cases. Diagnosis of GDM was made using oral glucose tolerance test with 75 g glucose. GDM patients were started on diet following which insulin or oral hypoglycemic agents were given if required. Maternal and perinatal outcome was noted in all women. RESULTS: The prevalence of GDM was 5.72% (170/2970). Most patients (79.41%) could be controlled on diet alone. However, 21 (12.35%) needed insulin and 14 (8.23%) needed oral hypoglycemic agents. Middle socioeconomic status was more common in GDM than control and pregnancy-induced hypertension was more common in GDM (13.5%) than in control (6.3%) (P = 0.019). Mode of delivery was not different in two groups. Instrumental deliveries and postpartum hemorrhage were also similar. However, mean birth weight was significantly higher in GDM (2848 ± 539 g) than in control (2707 ± 641 g) (P = 0.004). Incidence of large-for-date babies was also higher (28.2%) in GDM than control (19.4%) (P = 0.005). In neonatal complication, hypoglycemia was significantly higher in GDM (20.6%) than in control (5.2%) (P = 0.001). However, the incidence of hyperbilirubinemia and congenital malformations was not significantly different in two groups. CONCLUSION: The prevalence of GDM was 5.72% in this study. Adequate treatment of GDM on diet, oral hypoglycemic agents, or insulin to achieve euglycemia can achieve near-normal maternal and neonatal outcome. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5838890/ /pubmed/29535949 http://dx.doi.org/10.4103/ijem.IJEM_582_17 Text en Copyright: © 2018 Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kumari, Rajesh
Dalal, Venus
Kachhawa, Garima
Sahoo, Ipshita
Khadgawat, Rajesh
Mahey, Reeta
Kulshrestha, Vidushi
Vanamail, Perumal
Sharma, J. B.
Bhatla, Neerja
Kriplani, Alka
Maternal and Perinatal Outcome in Gestational Diabetes Mellitus in a Tertiary Care Hospital in Delhi
title Maternal and Perinatal Outcome in Gestational Diabetes Mellitus in a Tertiary Care Hospital in Delhi
title_full Maternal and Perinatal Outcome in Gestational Diabetes Mellitus in a Tertiary Care Hospital in Delhi
title_fullStr Maternal and Perinatal Outcome in Gestational Diabetes Mellitus in a Tertiary Care Hospital in Delhi
title_full_unstemmed Maternal and Perinatal Outcome in Gestational Diabetes Mellitus in a Tertiary Care Hospital in Delhi
title_short Maternal and Perinatal Outcome in Gestational Diabetes Mellitus in a Tertiary Care Hospital in Delhi
title_sort maternal and perinatal outcome in gestational diabetes mellitus in a tertiary care hospital in delhi
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838890/
https://www.ncbi.nlm.nih.gov/pubmed/29535949
http://dx.doi.org/10.4103/ijem.IJEM_582_17
work_keys_str_mv AT kumarirajesh maternalandperinataloutcomeingestationaldiabetesmellitusinatertiarycarehospitalindelhi
AT dalalvenus maternalandperinataloutcomeingestationaldiabetesmellitusinatertiarycarehospitalindelhi
AT kachhawagarima maternalandperinataloutcomeingestationaldiabetesmellitusinatertiarycarehospitalindelhi
AT sahooipshita maternalandperinataloutcomeingestationaldiabetesmellitusinatertiarycarehospitalindelhi
AT khadgawatrajesh maternalandperinataloutcomeingestationaldiabetesmellitusinatertiarycarehospitalindelhi
AT maheyreeta maternalandperinataloutcomeingestationaldiabetesmellitusinatertiarycarehospitalindelhi
AT kulshresthavidushi maternalandperinataloutcomeingestationaldiabetesmellitusinatertiarycarehospitalindelhi
AT vanamailperumal maternalandperinataloutcomeingestationaldiabetesmellitusinatertiarycarehospitalindelhi
AT sharmajb maternalandperinataloutcomeingestationaldiabetesmellitusinatertiarycarehospitalindelhi
AT bhatlaneerja maternalandperinataloutcomeingestationaldiabetesmellitusinatertiarycarehospitalindelhi
AT kriplanialka maternalandperinataloutcomeingestationaldiabetesmellitusinatertiarycarehospitalindelhi