Cargando…

Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion

BACKGROUND: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a complication of malaria with a lethality rate of up to 80% despite anti-malarial treatment. It is characterized by a vast infiltration of leukocytes, microhaemorrhages and vasogenic oedema in the lungs. Previously, a m...

Descripción completa

Detalles Bibliográficos
Autores principales: Vandermosten, Leen, Pham, Thao-Thy, Possemiers, Hendrik, Knoops, Sofie, Van Herck, Evelien, Deckers, Julie, Franke-Fayard, Blandine, Lamb, Tracey J., Janse, Chris J., Opdenakker, Ghislain, Van den Steen, Philippe E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839036/
https://www.ncbi.nlm.nih.gov/pubmed/29506544
http://dx.doi.org/10.1186/s12936-018-2251-3
_version_ 1783304353395769344
author Vandermosten, Leen
Pham, Thao-Thy
Possemiers, Hendrik
Knoops, Sofie
Van Herck, Evelien
Deckers, Julie
Franke-Fayard, Blandine
Lamb, Tracey J.
Janse, Chris J.
Opdenakker, Ghislain
Van den Steen, Philippe E.
author_facet Vandermosten, Leen
Pham, Thao-Thy
Possemiers, Hendrik
Knoops, Sofie
Van Herck, Evelien
Deckers, Julie
Franke-Fayard, Blandine
Lamb, Tracey J.
Janse, Chris J.
Opdenakker, Ghislain
Van den Steen, Philippe E.
author_sort Vandermosten, Leen
collection PubMed
description BACKGROUND: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a complication of malaria with a lethality rate of up to 80% despite anti-malarial treatment. It is characterized by a vast infiltration of leukocytes, microhaemorrhages and vasogenic oedema in the lungs. Previously, a mouse model for MA-ARDS was developed by infection of C57BL/6 mice with the Edinburgh line NK65-E of Plasmodium berghei. RESULTS: Here, both host and parasite factors were demonstrated to play crucial roles in the development and severity of lung pathology. In particular, the genetic constitution of the host was an important determinant in the development of MA-ARDS. Both male and female C57BL/6, but not BALB/c, mice developed MA-ARDS when infected with P. berghei NK65-E. However, the New York line of P. berghei NK65 (NK65-NY) did not induce demonstrable MA-ARDS, despite its accumulation in the lungs and fat tissue to a similar or even higher extent as P. berghei NK65-E. These two commonly used lines of P. berghei differ in their red blood cell preference. P. berghei NK65-NY showed a stronger predilection for reticulocytes than P. berghei NK65-E and this appeared to be associated with a lower pathogenicity in the lungs. The pulmonary pathology in the C57BL/6/P. berghei NK65-E model was more pronounced than in the model with infection of DBA/2 mice with P. berghei strain ANKA. The transient lung pathology in DBA/2 mice infected with P. berghei ANKA coincided with the infection phase in which parasites mainly infected normocytes. This phase was followed by a less pathogenic phase in which P. berghei ANKA mainly infected reticulocytes. CONCLUSIONS: The propensity of mice to develop MA-ARDS during P. berghei infection depends on both host and parasite factors and appears to correlate with RBC preference. These data provide insights in induction of MA-ARDS and may guide the choice of different mouse-parasite combinations to study lung pathology.
format Online
Article
Text
id pubmed-5839036
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-58390362018-03-09 Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion Vandermosten, Leen Pham, Thao-Thy Possemiers, Hendrik Knoops, Sofie Van Herck, Evelien Deckers, Julie Franke-Fayard, Blandine Lamb, Tracey J. Janse, Chris J. Opdenakker, Ghislain Van den Steen, Philippe E. Malar J Research BACKGROUND: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a complication of malaria with a lethality rate of up to 80% despite anti-malarial treatment. It is characterized by a vast infiltration of leukocytes, microhaemorrhages and vasogenic oedema in the lungs. Previously, a mouse model for MA-ARDS was developed by infection of C57BL/6 mice with the Edinburgh line NK65-E of Plasmodium berghei. RESULTS: Here, both host and parasite factors were demonstrated to play crucial roles in the development and severity of lung pathology. In particular, the genetic constitution of the host was an important determinant in the development of MA-ARDS. Both male and female C57BL/6, but not BALB/c, mice developed MA-ARDS when infected with P. berghei NK65-E. However, the New York line of P. berghei NK65 (NK65-NY) did not induce demonstrable MA-ARDS, despite its accumulation in the lungs and fat tissue to a similar or even higher extent as P. berghei NK65-E. These two commonly used lines of P. berghei differ in their red blood cell preference. P. berghei NK65-NY showed a stronger predilection for reticulocytes than P. berghei NK65-E and this appeared to be associated with a lower pathogenicity in the lungs. The pulmonary pathology in the C57BL/6/P. berghei NK65-E model was more pronounced than in the model with infection of DBA/2 mice with P. berghei strain ANKA. The transient lung pathology in DBA/2 mice infected with P. berghei ANKA coincided with the infection phase in which parasites mainly infected normocytes. This phase was followed by a less pathogenic phase in which P. berghei ANKA mainly infected reticulocytes. CONCLUSIONS: The propensity of mice to develop MA-ARDS during P. berghei infection depends on both host and parasite factors and appears to correlate with RBC preference. These data provide insights in induction of MA-ARDS and may guide the choice of different mouse-parasite combinations to study lung pathology. BioMed Central 2018-03-05 /pmc/articles/PMC5839036/ /pubmed/29506544 http://dx.doi.org/10.1186/s12936-018-2251-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Vandermosten, Leen
Pham, Thao-Thy
Possemiers, Hendrik
Knoops, Sofie
Van Herck, Evelien
Deckers, Julie
Franke-Fayard, Blandine
Lamb, Tracey J.
Janse, Chris J.
Opdenakker, Ghislain
Van den Steen, Philippe E.
Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion
title Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion
title_full Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion
title_fullStr Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion
title_full_unstemmed Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion
title_short Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion
title_sort experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839036/
https://www.ncbi.nlm.nih.gov/pubmed/29506544
http://dx.doi.org/10.1186/s12936-018-2251-3
work_keys_str_mv AT vandermostenleen experimentalmalariaassociatedacuterespiratorydistresssyndromeisdependentontheparasitehostcombinationandcoincideswithnormocyteinvasion
AT phamthaothy experimentalmalariaassociatedacuterespiratorydistresssyndromeisdependentontheparasitehostcombinationandcoincideswithnormocyteinvasion
AT possemiershendrik experimentalmalariaassociatedacuterespiratorydistresssyndromeisdependentontheparasitehostcombinationandcoincideswithnormocyteinvasion
AT knoopssofie experimentalmalariaassociatedacuterespiratorydistresssyndromeisdependentontheparasitehostcombinationandcoincideswithnormocyteinvasion
AT vanherckevelien experimentalmalariaassociatedacuterespiratorydistresssyndromeisdependentontheparasitehostcombinationandcoincideswithnormocyteinvasion
AT deckersjulie experimentalmalariaassociatedacuterespiratorydistresssyndromeisdependentontheparasitehostcombinationandcoincideswithnormocyteinvasion
AT frankefayardblandine experimentalmalariaassociatedacuterespiratorydistresssyndromeisdependentontheparasitehostcombinationandcoincideswithnormocyteinvasion
AT lambtraceyj experimentalmalariaassociatedacuterespiratorydistresssyndromeisdependentontheparasitehostcombinationandcoincideswithnormocyteinvasion
AT jansechrisj experimentalmalariaassociatedacuterespiratorydistresssyndromeisdependentontheparasitehostcombinationandcoincideswithnormocyteinvasion
AT opdenakkerghislain experimentalmalariaassociatedacuterespiratorydistresssyndromeisdependentontheparasitehostcombinationandcoincideswithnormocyteinvasion
AT vandensteenphilippee experimentalmalariaassociatedacuterespiratorydistresssyndromeisdependentontheparasitehostcombinationandcoincideswithnormocyteinvasion