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A critical appraisal on AIT in childhood asthma
ABSTRACT: Allergen immunotherapy (AIT) is the only disease-modifying treatment approved for allergic rhinitis and allergic asthma and represents a suitable therapeutic option, especially in childhood, to modify the progression of respiratory allergic diseases. Starting from the previous “generic cla...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839070/ https://www.ncbi.nlm.nih.gov/pubmed/29527129 http://dx.doi.org/10.1186/s12948-018-0085-8 |
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author | Ferrando, Matteo Racca, Francesca Madeira, Lorena Nascimento Girardi Heffler, Enrico Passalacqua, Giovanni Puggioni, Francesca Stomeo, Niccolò Canonica, Giorgio Walter |
author_facet | Ferrando, Matteo Racca, Francesca Madeira, Lorena Nascimento Girardi Heffler, Enrico Passalacqua, Giovanni Puggioni, Francesca Stomeo, Niccolò Canonica, Giorgio Walter |
author_sort | Ferrando, Matteo |
collection | PubMed |
description | ABSTRACT: Allergen immunotherapy (AIT) is the only disease-modifying treatment approved for allergic rhinitis and allergic asthma and represents a suitable therapeutic option, especially in childhood, to modify the progression of respiratory allergic diseases. Starting from the previous “generic class effect” evaluation, as testified by the numerous meta analyses, AIT is now considered a product-specific pathogenic-oriented treatment. BACKGROUND: AIT was empirically proposed more than one century ago in the subcutaneous form (SCIT), but the IgE-mediated mechanism of allergy was elucidated only after 50 years of clinical use of the treatment. The sublingual administration (SLIT) was developed during the 1980 ties, to achieve an improvement in safety and convenience. While SCIT is approved in the United States for the treatment of asthmatic patients with more than 12 years, so far few trials evaluated the clinical efficacy and safety of SLIT in children with allergic asthma, although the indications and some aspects remain unclear. Certainly, due to compliance problems, the age below 3 years may be reasonably considered a practical contraindication. CONCLUSIONS: Given that some specific AIT products are effective and approved as drugs (AIFA, EMA, FDA), the use in children is still debated. Some aspects still need robust confirm: (a) the safety of AIT in asthma; (b) the optimal regimen of administration; (c) the role of AIT as preventative treatment for asthma development. |
format | Online Article Text |
id | pubmed-5839070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-58390702018-03-09 A critical appraisal on AIT in childhood asthma Ferrando, Matteo Racca, Francesca Madeira, Lorena Nascimento Girardi Heffler, Enrico Passalacqua, Giovanni Puggioni, Francesca Stomeo, Niccolò Canonica, Giorgio Walter Clin Mol Allergy Review ABSTRACT: Allergen immunotherapy (AIT) is the only disease-modifying treatment approved for allergic rhinitis and allergic asthma and represents a suitable therapeutic option, especially in childhood, to modify the progression of respiratory allergic diseases. Starting from the previous “generic class effect” evaluation, as testified by the numerous meta analyses, AIT is now considered a product-specific pathogenic-oriented treatment. BACKGROUND: AIT was empirically proposed more than one century ago in the subcutaneous form (SCIT), but the IgE-mediated mechanism of allergy was elucidated only after 50 years of clinical use of the treatment. The sublingual administration (SLIT) was developed during the 1980 ties, to achieve an improvement in safety and convenience. While SCIT is approved in the United States for the treatment of asthmatic patients with more than 12 years, so far few trials evaluated the clinical efficacy and safety of SLIT in children with allergic asthma, although the indications and some aspects remain unclear. Certainly, due to compliance problems, the age below 3 years may be reasonably considered a practical contraindication. CONCLUSIONS: Given that some specific AIT products are effective and approved as drugs (AIFA, EMA, FDA), the use in children is still debated. Some aspects still need robust confirm: (a) the safety of AIT in asthma; (b) the optimal regimen of administration; (c) the role of AIT as preventative treatment for asthma development. BioMed Central 2018-03-06 /pmc/articles/PMC5839070/ /pubmed/29527129 http://dx.doi.org/10.1186/s12948-018-0085-8 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Ferrando, Matteo Racca, Francesca Madeira, Lorena Nascimento Girardi Heffler, Enrico Passalacqua, Giovanni Puggioni, Francesca Stomeo, Niccolò Canonica, Giorgio Walter A critical appraisal on AIT in childhood asthma |
title | A critical appraisal on AIT in childhood asthma |
title_full | A critical appraisal on AIT in childhood asthma |
title_fullStr | A critical appraisal on AIT in childhood asthma |
title_full_unstemmed | A critical appraisal on AIT in childhood asthma |
title_short | A critical appraisal on AIT in childhood asthma |
title_sort | critical appraisal on ait in childhood asthma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839070/ https://www.ncbi.nlm.nih.gov/pubmed/29527129 http://dx.doi.org/10.1186/s12948-018-0085-8 |
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