The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans

Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we exami...

Descripción completa

Detalles Bibliográficos
Autores principales: Munshi, Mansa A., Gardin, Justin M., Singh, Ashutosh, Luberto, Chiara, Rieger, Robert, Bouklas, Tejas, Fries, Bettina C., Poeta, Maurizio Del
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839121/
https://www.ncbi.nlm.nih.gov/pubmed/29425496
http://dx.doi.org/10.1016/j.celrep.2018.01.035
Descripción
Sumario:Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource for the fungal lipid research community in addition to discovering a potential target for antifungal therapy.

Ejemplares similares