The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans

Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we exami...

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Autores principales: Munshi, Mansa A., Gardin, Justin M., Singh, Ashutosh, Luberto, Chiara, Rieger, Robert, Bouklas, Tejas, Fries, Bettina C., Poeta, Maurizio Del
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839121/
https://www.ncbi.nlm.nih.gov/pubmed/29425496
http://dx.doi.org/10.1016/j.celrep.2018.01.035
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author Munshi, Mansa A.
Gardin, Justin M.
Singh, Ashutosh
Luberto, Chiara
Rieger, Robert
Bouklas, Tejas
Fries, Bettina C.
Poeta, Maurizio Del
author_facet Munshi, Mansa A.
Gardin, Justin M.
Singh, Ashutosh
Luberto, Chiara
Rieger, Robert
Bouklas, Tejas
Fries, Bettina C.
Poeta, Maurizio Del
author_sort Munshi, Mansa A.
collection PubMed
description Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource for the fungal lipid research community in addition to discovering a potential target for antifungal therapy.
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spelling pubmed-58391212018-03-06 The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans Munshi, Mansa A. Gardin, Justin M. Singh, Ashutosh Luberto, Chiara Rieger, Robert Bouklas, Tejas Fries, Bettina C. Poeta, Maurizio Del Cell Rep Article Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource for the fungal lipid research community in addition to discovering a potential target for antifungal therapy. 2018-02-06 /pmc/articles/PMC5839121/ /pubmed/29425496 http://dx.doi.org/10.1016/j.celrep.2018.01.035 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Munshi, Mansa A.
Gardin, Justin M.
Singh, Ashutosh
Luberto, Chiara
Rieger, Robert
Bouklas, Tejas
Fries, Bettina C.
Poeta, Maurizio Del
The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans
title The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans
title_full The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans
title_fullStr The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans
title_full_unstemmed The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans
title_short The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans
title_sort role of ceramide synthases in the pathogenicity of cryptococcus neoformans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839121/
https://www.ncbi.nlm.nih.gov/pubmed/29425496
http://dx.doi.org/10.1016/j.celrep.2018.01.035
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