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SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis

PURPOSE: Optic neuritis is a condition defined by autoimmune-mediated demyelination of the optic nerve and death of retinal ganglion cells. SIRT1 and NRF2 stimulate anti-inflammatory mechanisms and have previously demonstrated therapeutic value in preclinical models of neurodegenerative disease. Her...

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Detalles Bibliográficos
Autores principales:	McDougald, Devin S., Dine, Kimberly E., Zezulin, Alexandra U., Bennett, Jean, Shindler, Kenneth S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2018
Materias:	Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839257/ https://www.ncbi.nlm.nih.gov/pubmed/29494741 http://dx.doi.org/10.1167/iovs.17-22972

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