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Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients

BACKGROUND: Uremia is a vasculopathic process, and both cardiac calcification and vascular calcification seen from the early stages of chronic kidney disease. Osteoprotegerin could play a crucial role in atherosclerotic plaque formation, maturation and calcification. The goal of this study was to de...

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Autores principales: El Baz, Tarek Z., Khamis, Osama A., El-Shehaby, Amal, Chahine, Hussein, Alaa Al-Din Ahmed, Ahmad, Alsawasany, Mostafa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Egyptian Society of Cardiology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839346/
https://www.ncbi.nlm.nih.gov/pubmed/29622969
http://dx.doi.org/10.1016/j.ehj.2017.02.004
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author El Baz, Tarek Z.
Khamis, Osama A.
El-Shehaby, Amal
Chahine, Hussein
Alaa Al-Din Ahmed, Ahmad
Alsawasany, Mostafa A.
author_facet El Baz, Tarek Z.
Khamis, Osama A.
El-Shehaby, Amal
Chahine, Hussein
Alaa Al-Din Ahmed, Ahmad
Alsawasany, Mostafa A.
author_sort El Baz, Tarek Z.
collection PubMed
description BACKGROUND: Uremia is a vasculopathic process, and both cardiac calcification and vascular calcification seen from the early stages of chronic kidney disease. Osteoprotegerin could play a crucial role in atherosclerotic plaque formation, maturation and calcification. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with end stage kidney disease who were maintained on regular hemodialysis. METHODS: Sixty clinically stable chronic renal failure patients undergoing regular hemodialysis were enrolled in this cross sectional study. Thirty patients (mean age 56.7 ± 10.5 years) with abdominal aortic calcification were selected by basal abdominal X-ray who underwent multi-slice computerized tomography scan to measure coronary artery calcification score; and thirty patients (mean age 56.5 ± 8.4 years) without abdominal aortic calcification. All patients were evaluated by serum calcium, phosphorus, albumin, lipid profile, intact parathyroid hormone (iPTH), serum creatinine, serum urea, serum uric acid, serum C-reactive protein, and hemoglobin. Serum osteoprotegerin samples were collected before dialysis and estimated by the ELISA kit. RESULTS: Serum osteoprotegerin level was significantly higher in patients with vascular calcification than in those without calcifications. Serum osteoprotegerin correlated positively with serum phosphorus, calcium phosphorus product, alkaline phosphatase, iPTH, C-reactive protein, serum uric acid, low-density lipoprotein (LDL) and left ventricular mass index (LVMI) (p < 0.005), and negatively with hemoglobin, ejection fraction (p < 0.005) and HDL (p < 0.05). CONCLUSIONS: These findings suggest that osteoprotegerin may be involved in the development of vascular calcification in hemodialysis patients.
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spelling pubmed-58393462018-04-05 Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients El Baz, Tarek Z. Khamis, Osama A. El-Shehaby, Amal Chahine, Hussein Alaa Al-Din Ahmed, Ahmad Alsawasany, Mostafa A. Egypt Heart J Miscellaneous BACKGROUND: Uremia is a vasculopathic process, and both cardiac calcification and vascular calcification seen from the early stages of chronic kidney disease. Osteoprotegerin could play a crucial role in atherosclerotic plaque formation, maturation and calcification. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with end stage kidney disease who were maintained on regular hemodialysis. METHODS: Sixty clinically stable chronic renal failure patients undergoing regular hemodialysis were enrolled in this cross sectional study. Thirty patients (mean age 56.7 ± 10.5 years) with abdominal aortic calcification were selected by basal abdominal X-ray who underwent multi-slice computerized tomography scan to measure coronary artery calcification score; and thirty patients (mean age 56.5 ± 8.4 years) without abdominal aortic calcification. All patients were evaluated by serum calcium, phosphorus, albumin, lipid profile, intact parathyroid hormone (iPTH), serum creatinine, serum urea, serum uric acid, serum C-reactive protein, and hemoglobin. Serum osteoprotegerin samples were collected before dialysis and estimated by the ELISA kit. RESULTS: Serum osteoprotegerin level was significantly higher in patients with vascular calcification than in those without calcifications. Serum osteoprotegerin correlated positively with serum phosphorus, calcium phosphorus product, alkaline phosphatase, iPTH, C-reactive protein, serum uric acid, low-density lipoprotein (LDL) and left ventricular mass index (LVMI) (p < 0.005), and negatively with hemoglobin, ejection fraction (p < 0.005) and HDL (p < 0.05). CONCLUSIONS: These findings suggest that osteoprotegerin may be involved in the development of vascular calcification in hemodialysis patients. Egyptian Society of Cardiology 2017-06 2017-03-09 /pmc/articles/PMC5839346/ /pubmed/29622969 http://dx.doi.org/10.1016/j.ehj.2017.02.004 Text en © 2017 Egyptian Society of Cardiology. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Miscellaneous
El Baz, Tarek Z.
Khamis, Osama A.
El-Shehaby, Amal
Chahine, Hussein
Alaa Al-Din Ahmed, Ahmad
Alsawasany, Mostafa A.
Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients
title Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients
title_full Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients
title_fullStr Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients
title_full_unstemmed Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients
title_short Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients
title_sort relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients
topic Miscellaneous
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839346/
https://www.ncbi.nlm.nih.gov/pubmed/29622969
http://dx.doi.org/10.1016/j.ehj.2017.02.004
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