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Value of global longitudinal strain by two dimensional speckle tracking echocardiography in predicting coronary artery disease severity

BACKGROUND: Significant coronary artery stenosis might cause persistently impaired longitudinal left ventricle (LV) function at rest. LV global longitudinal strain (LVGLS) can be accurately assessed by 2D speckle-tracking strain echocardiography(2D-STE). OBJECTIVE: We aimed to evaluate the diagnosti...

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Autores principales: Radwan, Hanan, Hussein, Ekhlas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Egyptian Society of Cardiology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839366/
https://www.ncbi.nlm.nih.gov/pubmed/29622962
http://dx.doi.org/10.1016/j.ehj.2016.08.001
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author Radwan, Hanan
Hussein, Ekhlas
author_facet Radwan, Hanan
Hussein, Ekhlas
author_sort Radwan, Hanan
collection PubMed
description BACKGROUND: Significant coronary artery stenosis might cause persistently impaired longitudinal left ventricle (LV) function at rest. LV global longitudinal strain (LVGLS) can be accurately assessed by 2D speckle-tracking strain echocardiography(2D-STE). OBJECTIVE: We aimed to evaluate the diagnostic accuracy of LV global longitudinal strain obtained by 2D-STE in prediction of severity of CAD. METHODS: Eighty patients with suspected stable angina pectoris were included. They underwent transthoracic echocardiography (TTE) to measure LV ejection fraction, 2-D-STE to measure GLS and coronary angiography (CA). The patients were divided into two groups: group 1 (58 patients) with significant (>70%) CAD, and group 2 (22 patients) with non-significant (<70%) CAD. Images were obtained in the apical long-axis, four-chamber, and two chamber views. Regional longitudinal systolic strain was measured in 17 myocardial segments and averaged to provide global longitudinal strain (LVGLS). RESULTS: There was significant decrease in GLS in group 1 compared to group 2 (−11.86 ± 2.89% versus −18.65 ± 0.79%, P < 0.000). The optimal cutoff value of GLS for prediction of significant CAD was −15.6% [AUC 0.88, 95% CI 0.78–0.96 p < 0.000]. The sensitivity, specificity and accuracy of GLS for detecting significant CAD were 93.1%, 81.8%,and 90% respectively.There was a significant positive correlation between GLS and EF (r = 0.33; p = 0.036).There was incremental significant decrease in GLS with increasing number of coronary vessels involved. CONCLUSION: Measurement of global longitudinal strain using 2D speckle tracking echocardiography is sensitive and accurate tool in the prediction of severe CAD.
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spelling pubmed-58393662018-04-05 Value of global longitudinal strain by two dimensional speckle tracking echocardiography in predicting coronary artery disease severity Radwan, Hanan Hussein, Ekhlas Egypt Heart J Echocardiography BACKGROUND: Significant coronary artery stenosis might cause persistently impaired longitudinal left ventricle (LV) function at rest. LV global longitudinal strain (LVGLS) can be accurately assessed by 2D speckle-tracking strain echocardiography(2D-STE). OBJECTIVE: We aimed to evaluate the diagnostic accuracy of LV global longitudinal strain obtained by 2D-STE in prediction of severity of CAD. METHODS: Eighty patients with suspected stable angina pectoris were included. They underwent transthoracic echocardiography (TTE) to measure LV ejection fraction, 2-D-STE to measure GLS and coronary angiography (CA). The patients were divided into two groups: group 1 (58 patients) with significant (>70%) CAD, and group 2 (22 patients) with non-significant (<70%) CAD. Images were obtained in the apical long-axis, four-chamber, and two chamber views. Regional longitudinal systolic strain was measured in 17 myocardial segments and averaged to provide global longitudinal strain (LVGLS). RESULTS: There was significant decrease in GLS in group 1 compared to group 2 (−11.86 ± 2.89% versus −18.65 ± 0.79%, P < 0.000). The optimal cutoff value of GLS for prediction of significant CAD was −15.6% [AUC 0.88, 95% CI 0.78–0.96 p < 0.000]. The sensitivity, specificity and accuracy of GLS for detecting significant CAD were 93.1%, 81.8%,and 90% respectively.There was a significant positive correlation between GLS and EF (r = 0.33; p = 0.036).There was incremental significant decrease in GLS with increasing number of coronary vessels involved. CONCLUSION: Measurement of global longitudinal strain using 2D speckle tracking echocardiography is sensitive and accurate tool in the prediction of severe CAD. Egyptian Society of Cardiology 2017-06 2016-08-29 /pmc/articles/PMC5839366/ /pubmed/29622962 http://dx.doi.org/10.1016/j.ehj.2016.08.001 Text en © 2016 Egyptian Society of Cardiology. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Echocardiography
Radwan, Hanan
Hussein, Ekhlas
Value of global longitudinal strain by two dimensional speckle tracking echocardiography in predicting coronary artery disease severity
title Value of global longitudinal strain by two dimensional speckle tracking echocardiography in predicting coronary artery disease severity
title_full Value of global longitudinal strain by two dimensional speckle tracking echocardiography in predicting coronary artery disease severity
title_fullStr Value of global longitudinal strain by two dimensional speckle tracking echocardiography in predicting coronary artery disease severity
title_full_unstemmed Value of global longitudinal strain by two dimensional speckle tracking echocardiography in predicting coronary artery disease severity
title_short Value of global longitudinal strain by two dimensional speckle tracking echocardiography in predicting coronary artery disease severity
title_sort value of global longitudinal strain by two dimensional speckle tracking echocardiography in predicting coronary artery disease severity
topic Echocardiography
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839366/
https://www.ncbi.nlm.nih.gov/pubmed/29622962
http://dx.doi.org/10.1016/j.ehj.2016.08.001
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