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A phase-1/2 study of adenovirus-p53 transduced dendritic cell vaccine in combination with indoximod in metastatic solid tumors and invasive breast cancer

BACKGROUND: Indoleamine 2, 3-dioxygenase is an enzyme that causes immunosuppression in tumors. Indoximod inhibits the indoleamine 2, 3-dioxygenase pathway and enhances immunologic responses to dendritic cell (DC) vaccines preclinically. Adenovirus p53 (Ad.p53) is used to generate DC vaccines against...

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Detalles Bibliográficos
Autores principales:	Soliman, Hatem, Khambati, Fatema, Han, Hyo S., Ismail-Khan, Roohi, Bui, Marilyn M., Sullivan, Daniel M., Antonia, Scott
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Clinical Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839376/ https://www.ncbi.nlm.nih.gov/pubmed/29515795 http://dx.doi.org/10.18632/oncotarget.24118

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