Impact of the number of mutations in survival and response outcomes to hypomethylating agents in patients with myelodysplastic syndromes or myelodysplastic/myeloproliferative neoplasms

The prognostic and predictive value of sequencing analysis in myelodysplastic syndromes (MDS) has not been fully integrated into clinical practice. We performed whole exome sequencing (WES) of bone marrow samples from 83 patients with MDS and 31 with MDS/MPN identifying 218 driver mutations in 31 ge...

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Detalles Bibliográficos
Autores principales: Montalban-Bravo, Guillermo, Takahashi, Koichi, Patel, Keyur, Wang, Feng, Xingzhi, Song, Nogueras, Graciela M., Huang, Xuelin, Pierola, Ana Alfonso, Jabbour, Elias, Colla, Simona, Gañan-Gomez, Irene, Borthakur, Gautham, Daver, Naval, Estrov, Zeev, Kadia, Tapan, Pemmaraju, Naveen, Ravandi, Farhad, Bueso-Ramos, Carlos, Chamseddine, Ali, Konopleva, Marina, Zhang, Jianhua, Kantarjian, Hagop, Futreal, Andrew, Garcia-Manero, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839396/
https://www.ncbi.nlm.nih.gov/pubmed/29515765
http://dx.doi.org/10.18632/oncotarget.23882

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