Reversible LSD1 inhibition with HCI-2509 induces the p53 gene expression signature and disrupts the MYCN signature in high-risk neuroblastoma cells

Lysine-Specific Demethylase 1 (LSD1) over-expression correlates with poorly differentiated neuroblastoma and predicts poor outcome despite multimodal therapy. We have studied the efficacy of reversible and specific LSD1 inhibition with HCI-2509 in neuroblastoma cell lines and particularly the effect...

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Detalles Bibliográficos
Autores principales: Gupta, Sumati, Doyle, Kelly, Mosbruger, Timothy L., Butterfield, Andrew, Weston, Alexis, Ast, Allison, Kaadige, Mohan, Verma, Anupam, Sharma, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839410/
https://www.ncbi.nlm.nih.gov/pubmed/29515779
http://dx.doi.org/10.18632/oncotarget.24035

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