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Dual enhancement mechanisms for overnight motor memory consolidation

Our brains are constantly processing past events [1]. These off-line processes consolidate memories, leading in the case of motor skill memories to an enhancement in performance between training sessions. A similar magnitude of enhancement develops over a night of sleep following an implicit task, w...

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Detalles Bibliográficos
Autores principales: Breton, Jocelyn, Robertson, Edwin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839513/
https://www.ncbi.nlm.nih.gov/pubmed/29520375
http://dx.doi.org/10.1038/s41562-017-0111
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author Breton, Jocelyn
Robertson, Edwin M.
author_facet Breton, Jocelyn
Robertson, Edwin M.
author_sort Breton, Jocelyn
collection PubMed
description Our brains are constantly processing past events [1]. These off-line processes consolidate memories, leading in the case of motor skill memories to an enhancement in performance between training sessions. A similar magnitude of enhancement develops over a night of sleep following an implicit task, when a sequence of movements is acquired unintentionally, or following an explicit task, when the same sequence is acquired intentionally [2]. What remains poorly understood, however, is whether these similar offline improvements are supported by similar circuits, or through distinct circuits. We set out to distinguish between these possibilities by applying Transcranial Magnetic Stimulation (TMS), over the primary motor cortex (M1) or the inferior parietal lobule (IPL) immediately after learning in either the explicit or implicit task. These brain areas have both been implicated in encoding aspects of a motor sequence, and subsequently supporting offline improvements over sleep [3–5]. Here we show that offline improvements following the explicit task are dependent upon a circuit that includes M1 but not IPL. By contrast, offline improvements following the implicit task are dependent upon a circuit that includes IPL but not M1. Our work establishes the critical contribution made by M1 and IPL circuits to offline memory processing, and reveals that distinct circuits support similar offline improvements.
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spelling pubmed-58395132018-03-06 Dual enhancement mechanisms for overnight motor memory consolidation Breton, Jocelyn Robertson, Edwin M. Nat Hum Behav Article Our brains are constantly processing past events [1]. These off-line processes consolidate memories, leading in the case of motor skill memories to an enhancement in performance between training sessions. A similar magnitude of enhancement develops over a night of sleep following an implicit task, when a sequence of movements is acquired unintentionally, or following an explicit task, when the same sequence is acquired intentionally [2]. What remains poorly understood, however, is whether these similar offline improvements are supported by similar circuits, or through distinct circuits. We set out to distinguish between these possibilities by applying Transcranial Magnetic Stimulation (TMS), over the primary motor cortex (M1) or the inferior parietal lobule (IPL) immediately after learning in either the explicit or implicit task. These brain areas have both been implicated in encoding aspects of a motor sequence, and subsequently supporting offline improvements over sleep [3–5]. Here we show that offline improvements following the explicit task are dependent upon a circuit that includes M1 but not IPL. By contrast, offline improvements following the implicit task are dependent upon a circuit that includes IPL but not M1. Our work establishes the critical contribution made by M1 and IPL circuits to offline memory processing, and reveals that distinct circuits support similar offline improvements. 2017-05-15 2017-06 /pmc/articles/PMC5839513/ /pubmed/29520375 http://dx.doi.org/10.1038/s41562-017-0111 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Breton, Jocelyn
Robertson, Edwin M.
Dual enhancement mechanisms for overnight motor memory consolidation
title Dual enhancement mechanisms for overnight motor memory consolidation
title_full Dual enhancement mechanisms for overnight motor memory consolidation
title_fullStr Dual enhancement mechanisms for overnight motor memory consolidation
title_full_unstemmed Dual enhancement mechanisms for overnight motor memory consolidation
title_short Dual enhancement mechanisms for overnight motor memory consolidation
title_sort dual enhancement mechanisms for overnight motor memory consolidation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839513/
https://www.ncbi.nlm.nih.gov/pubmed/29520375
http://dx.doi.org/10.1038/s41562-017-0111
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