RNA activating-double stranded RNA targeting flt-1 promoter inhibits endothelial cell proliferation through soluble FLT-1 upregulation

Short-activating RNA (saRNA), which targets gene promoters, has been shown to increase the target gene expression. In this study, we describe the use of an saRNA (Flt a-1) to target the flt-1 promoter, leading to upregulation of the soluble isoform of Flt-1 and inhibition of angiogenesis. We demonst...

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Detalles Bibliográficos
Autores principales: Choi, Susie, Uehara, Hironori, Wu, Yuanyuan, Das, Subrata, Zhang, Xiaohui, Archer, Bonnie, Carroll, Lara, Ambati, Balamurali Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839558/
https://www.ncbi.nlm.nih.gov/pubmed/29509796
http://dx.doi.org/10.1371/journal.pone.0193590

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