Neutrophil-generated HOCl leads to non-specific thiol oxidation in phagocytized bacteria

Phagocytic immune cells kill pathogens in the phagolysosomal compartment with a cocktail of antimicrobial agents. Chief among them are reactive species produced in the so-called oxidative burst. Here, we show that bacteria exposed to a neutrophil-like cell line experience a rapid and massive oxidati...

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Detalles Bibliográficos
Autores principales: Degrossoli, Adriana, Müller, Alexandra, Xie, Kaibo, Schneider, Jannis F, Bader, Verian, Winklhofer, Konstanze F, Meyer, Andreas J, Leichert, Lars I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839695/
https://www.ncbi.nlm.nih.gov/pubmed/29506649
http://dx.doi.org/10.7554/eLife.32288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839695/
https://www.ncbi.nlm.nih.gov/pubmed/29506649
http://dx.doi.org/10.7554/eLife.32288

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