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How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration?
SIGNIFICANCE: The American Academy of Ophthalmology currently recommends against routine genetic testing for complex diseases such as age-related macular degeneration (AMD). The results of this study demonstrate that patients are very interested in predictive genetic testing for AMD, find the inform...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839714/ https://www.ncbi.nlm.nih.gov/pubmed/29424826 http://dx.doi.org/10.1097/OPX.0000000000001188 |
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author | McCarty, Catherine A. Fuchs, Michael J. Lamb, Allan Conway, Pat |
author_facet | McCarty, Catherine A. Fuchs, Michael J. Lamb, Allan Conway, Pat |
author_sort | McCarty, Catherine A. |
collection | PubMed |
description | SIGNIFICANCE: The American Academy of Ophthalmology currently recommends against routine genetic testing for complex diseases such as age-related macular degeneration (AMD). The results of this study demonstrate that patients are very interested in predictive genetic testing for AMD, find the information useful, and make behavioral changes as a result of the information. PURPOSE: The goal of this project was to conduct a pilot AMD genomic medicine study. METHODS: Eligible patients were aged 50 to 65 years with no personal history of AMD. DNA samples were genotyped for five single-nucleotide polymorphisms (SNPs) in the CFH gene, one SNP in the ARMS-2 gene, one SNP in the C3 gene, and one SNP in the mitochondrial ND2 gene. A risk score was calculated utilizing a model based on odds ratios, lifetime risk of advanced AMD and known population prevalence of genotype, haplotype, and smoking risk. The study optometrist provided the patient's risk score and counseling for personal protective behaviors. Telephone interviews were conducted 1 to 3 months after the counseling visit. RESULTS: One hundred one subjects (85%) participated in the genetic testing; 78 (77.2%) were female. Follow-up interviews were conducted with 94 participants (93.1%). More than half (n = 48) of the participants said that they were motivated to participate in the study because they had a family member with AMD or another eye or genetic disorder. Despite low risk levels, many participants reported making changes as a result of the genetic testing. Twenty-seven people reported making specific changes, including wearing sunglasses and brimmed hat and taking vitamin supplements. Another 16 people said that they were already doing the recommended activities, including wearing glasses, quitting smoking, and/or taking vitamins. CONCLUSIONS: Interest in genetic testing for future risk of AMD was high in this population and resulted in support to continue current health behaviors or incentive to improve behaviors related to eye health. |
format | Online Article Text |
id | pubmed-5839714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-58397142018-03-20 How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration? McCarty, Catherine A. Fuchs, Michael J. Lamb, Allan Conway, Pat Optom Vis Sci Feature Article–Public Access SIGNIFICANCE: The American Academy of Ophthalmology currently recommends against routine genetic testing for complex diseases such as age-related macular degeneration (AMD). The results of this study demonstrate that patients are very interested in predictive genetic testing for AMD, find the information useful, and make behavioral changes as a result of the information. PURPOSE: The goal of this project was to conduct a pilot AMD genomic medicine study. METHODS: Eligible patients were aged 50 to 65 years with no personal history of AMD. DNA samples were genotyped for five single-nucleotide polymorphisms (SNPs) in the CFH gene, one SNP in the ARMS-2 gene, one SNP in the C3 gene, and one SNP in the mitochondrial ND2 gene. A risk score was calculated utilizing a model based on odds ratios, lifetime risk of advanced AMD and known population prevalence of genotype, haplotype, and smoking risk. The study optometrist provided the patient's risk score and counseling for personal protective behaviors. Telephone interviews were conducted 1 to 3 months after the counseling visit. RESULTS: One hundred one subjects (85%) participated in the genetic testing; 78 (77.2%) were female. Follow-up interviews were conducted with 94 participants (93.1%). More than half (n = 48) of the participants said that they were motivated to participate in the study because they had a family member with AMD or another eye or genetic disorder. Despite low risk levels, many participants reported making changes as a result of the genetic testing. Twenty-seven people reported making specific changes, including wearing sunglasses and brimmed hat and taking vitamin supplements. Another 16 people said that they were already doing the recommended activities, including wearing glasses, quitting smoking, and/or taking vitamins. CONCLUSIONS: Interest in genetic testing for future risk of AMD was high in this population and resulted in support to continue current health behaviors or incentive to improve behaviors related to eye health. Lippincott Williams & Wilkins 2018-03 2018-02-08 /pmc/articles/PMC5839714/ /pubmed/29424826 http://dx.doi.org/10.1097/OPX.0000000000001188 Text en Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Optometry. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Feature Article–Public Access McCarty, Catherine A. Fuchs, Michael J. Lamb, Allan Conway, Pat How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration? |
title | How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration? |
title_full | How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration? |
title_fullStr | How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration? |
title_full_unstemmed | How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration? |
title_short | How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration? |
title_sort | how do patients respond to genetic testing for age-related macular degeneration? |
topic | Feature Article–Public Access |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839714/ https://www.ncbi.nlm.nih.gov/pubmed/29424826 http://dx.doi.org/10.1097/OPX.0000000000001188 |
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